{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:09Z","timestamp":1777902009990,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Acute respiratory distress syndrome (ARDS) is a clinical condition characterized by damage and inflammation of the alveolar-capillary membrane, which is associated with high incidence and mortality rates. Metabolomics, a significant field of systematic biology, provides a novel perspective for understanding the pathophysiological mechanisms underlying ARDS by analyzing small molecule metabolites in biological samples. This narrative review explores the application of metabolomics in ARDS.<\/jats:p>","DOI":"10.1177\/00368504251356317","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:57:31Z","timestamp":1753945051000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of metabolomics in acute respiratory distress syndrome: A narrative review"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6343-4649","authenticated-orcid":false,"given":"Xiu-yan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0558WS"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4827-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21670"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01686-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112138-20230120-00029"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.32"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90168-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.3.720"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"e_1_3_3_13_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Force ADT","year":"2012","unstructured":"Force ADT, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012; 307: 2526\u20132533.","journal-title":"JAMA"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21907"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61623-1"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30171-6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401520"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00460-5"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.25"},{"key":"e_1_3_3_20_2","article-title":"Metabolomics of sepsis-induced acute lung injury: a new approach for biomarkers","volume":"300","author":"Lacy P","year":"2011","unstructured":"Lacy P. Metabolomics of sepsis-induced acute lung injury: a new approach for biomarkers. Am J Phys-Lung Cellu Mole Phys 2011; 300: L1\u2013L3.","journal-title":"Am J Phys-Lung Cellu Mole Phys"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/4551054a"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3782"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.376"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.043"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01333-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1125582"},{"key":"e_1_3_3_27_2","volume-title":"Molecular in vitro diagnostic examinations - specifications for pre examination processes in metabolomics in urine, venous blood serum and plasma","author":"ISO","year":"2021","unstructured":"ISO. Molecular in vitro diagnostic examinations - specifications for pre examination processes in metabolomics in urine, venous blood serum and plasma. Berlin, Germany: Springer, 2021."},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2022.01.006"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1AN15605E"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2020.106462"},{"key":"e_1_3_3_31_2","article-title":"Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury","volume":"295","author":"Serkova NJ","year":"2008","unstructured":"Serkova NJ, Van Rheen Z, Tobias M, et al. Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury. Am J Phys-Lung Cellu Mole Phys 2008; 295: L152\u2013L161.","journal-title":"Am J Phys-Lung Cellu Mole Phys"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00685.2013"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00306"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00214-2023"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00788"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2019.02.009"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr4007624"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04552-0"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00005614"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04882-7"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.09.004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70097-9"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051340"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201603-0645OC"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30177-2"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181d451ec"},{"key":"e_1_3_3_47_2","article-title":"ARDS metabolic fingerprints: characterization, benchmarking, and potential mechanistic interpretation","volume":"321","author":"Metwaly S","year":"2021","unstructured":"Metwaly S, C\u00f4t\u00e9 A, Donnelly SJ, et al. ARDS metabolic fingerprints: characterization, benchmarking, and potential mechanistic interpretation. Am J Phys\u2014Lung Cellu Mole Phys 2021; 321: L79\u2013L90.","journal-title":"Am J Phys\u2014Lung Cellu Mole Phys"},{"key":"e_1_3_3_48_2","article-title":"Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS","volume":"324","author":"Alipanah-Lechner N","year":"2023","unstructured":"Alipanah-Lechner N, Neyton L, Mick E, et al. Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS. Am J Phys\u2013Lung Cellu Mole Phys 2023; 324: L297\u2013L306.","journal-title":"Am J Phys\u2013Lung Cellu Mole Phys"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03810-3"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05634-w"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-023-00609-6"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201700112"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39017-4"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187545"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05000-3"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0758-3"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01364-6"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0114-2020"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02075-w"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251356317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251356317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251356317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:16:41Z","timestamp":1777634201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251356317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/00368504251356317"],"URL":"https:\/\/doi.org\/10.1177\/00368504251356317","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"article-number":"00368504251356317"}}