{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:41:30Z","timestamp":1789450890785,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Project of Clinical Outstanding Discipline Construction in Shanghai Pudong New Area","award":["(No. PWYgy2021-09)"],"award-info":[{"award-number":["(No. PWYgy2021-09)"]}]},{"name":"Discipline Leader Training Program of the Pudong New Area Health System, Shanghai","award":["\uff08 No. PWRd2024-12\uff09"],"award-info":[{"award-number":["\uff08 No. PWRd2024-12\uff09"]}]},{"name":"Talent Development Program Plan of the Qihang Program at Pudong New District People's Hospital, Shanghai","award":["PRYQH202302"],"award-info":[{"award-number":["PRYQH202302"]}]},{"name":"The Project of Key Medical Discipline Group Construction in Shanghai Pudong New Area","award":["(No. PWZxq2022-13)"],"award-info":[{"award-number":["(No. PWZxq2022-13)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study explores the prognostic value of combining the PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio and nonthyroidal illness syndrome (NTIS) for predicting 28-day mortality in patients with sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted using data from adult sepsis patients admitted to the ICU in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were divided into four groups based on PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio levels and the presence of NTIS (Groups 1\u20134). Kaplan\u2013Meier (K-M) analysis with the log-rank test was used to compare 28-day mortality among groups. Multivariate Cox regression was performed to evaluate the independent association between group classification and mortality. A restricted cubic spline (RCS) was used to explore the relationship between PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio and 28-day mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 599 sepsis patients were included in the analysis. Among the four P\/F\u2013NTIS stratified groups, Group 4 (P\/F\u2009\u2264\u2009200\u2005mmHg with NTIS) exhibited the highest 28-day mortality rate (37.11%), significantly higher than Groups 1, 2, and 3 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001). K-M analysis revealed a significantly lower survival probability in Group 4 (log-rank test,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Univariate Cox regression analysis identified P\/F\u2013NTIS classification as significant predictors of 28-day mortality. Multivariate Cox regression analysis confirmed that Group 4 was independently associated with increased 28-day mortality (HR\u2009=\u20091.70, 95% CI [1.08\u20132.69],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.022). RCS analysis showed a nonlinear but statistically significant association between P\/F ratio and 28-day mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for nonlinearity\u2009=\u2009.242), further supporting the prognostic relevance of oxygenation status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined evaluation of the P\/F and NTIS provides a more comprehensive risk stratification approach, allowing for improved 28-day mortality prediction in septic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251359356","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:42:18Z","timestamp":1753252938000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comorbidity of PaO\n                    <sub>2<\/sub>\n                    \/FiO\n                    <sub>2<\/sub>\n                    and nonthyroidal illness syndrome synergistically predicts 28-day mortality in sepsis: A retrospective cohort study from the MIMIC-IV database"],"prefix":"10.1177","volume":"108","author":[{"given":"Wei","family":"Song","sequence":"first","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wan","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Chen","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong hui","family":"Fan","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"Wu","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Han","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixue","family":"Wu","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pudong New Area People's Hospital, Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10102075"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00330-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211004759"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2015.02.038"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2663-7"},{"key":"e_1_3_3_9_2","first-page":"111","article-title":"Predictive value of oxygenation index at intensive care unit admission for 30-day mortality in patients with sepsis","volume":"37","author":"Bi C","year":"2025","unstructured":"Bi C, Zhu M, Ni C, et al. 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