{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:03:28Z","timestamp":1787018608370,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between systemic immune-inflammation indices and the severity of obstructive sleep apnea syndrome (OSAS). Specifically, we evaluated whether the Systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and pan-immune inflammation value (PIV) could serve as predictive or supplementary markers for OSAS prognosis and severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross-sectional analysis was conducted on 263 patients diagnosed with OSAS. Based on the apnea-hypopnea index (AHI), patients were categorized into three groups: mild, moderate, and severe OSAS. Inflammatory markers including SII, SIRI, NLR, and PIV were calculated using routine hematological parameters and compared across the groups to determine their association with disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All examined inflammatory indices (NLR, SII, SIRI, and PIV) showed statistically significant differences across the OSAS severity groups. Specifically, these markers were significantly elevated in the severe OSAS group compared to the mild and moderate groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The results support the hypothesis that increased systemic inflammation is associated with more severe forms of OSAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammatory markers such as SII, SIRI, NLR, and PIV may serve as useful tools in assessing OSAS severity and could assist in clinical decision-making. Given their ease of calculation from standard blood tests, these indices may offer practical value in evaluating prognosis and tailoring treatment strategies for patients with OSAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251365874","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:35:21Z","timestamp":1756128921000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of inflammatory markers in obstructive sleep apnea syndrome"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-7281","authenticated-orcid":false,"given":"Yildiz","family":"Ucar","sequence":"first","affiliation":[{"name":"Ba\u015fkent University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Yonar","sequence":"additional","affiliation":[{"name":"Selcuk University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0726-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6394"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2001008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00580-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"e_1_3_3_8_2","first-page":"631","article-title":"Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?","volume":"64","author":"Ryan S","year":"2009","unstructured":"Ryan S, Taylor CT, McNicholas WT. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 2009; 64: 631\u2013636.","journal-title":"Thorax"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66152-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_3_3_11_2","volume-title":"The AASM manual for the scoring of sleep and associated events: Rules, terminology and technical specifications (Version 2.0)","author":"Berry RB","year":"2012","unstructured":"Berry RB, Brooks R, Gamaldo CE, et al. The AASM manual for the scoring of sleep and associated events: Rules, terminology and technical specifications (Version 2.0). 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