{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:53:34Z","timestamp":1780365214374,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008727","name":"Fundaci\u00f3n Cardioinfantil - Instituto de Cardiolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008727","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n Neumol\u00f3gica Colombiana"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pulmonary hypertension is a heterogeneous syndrome with diverse underlying etiologies. This study aimed to evaluate the association between preoperative hemodynamic parameters\u2014assessed by right heart catheterization (RHC) and transthoracic echocardiography (TTE)\u2014and histopathological findings in explanted lungs from transplant recipients residing at high altitude.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of lung transplant recipients with interstitial lung disease (ILD) who had available RHC and TTE data prior to transplantation. Clinical, functional, hemodynamic, and histopathological variables were collected to assess the presence and severity of pulmonary vasculopathy. Bivariate analyses, correlation tests, and internally validated predictive models were performed to explore these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 38 patients were included (median age: 54 years). The median mean pulmonary artery pressure (mPAP) was 33\u2005mmHg, and the pulmonary artery systolic pressure (PASP) was 42\u2005mmHg. An inverse correlation was observed between vasculopathy grade and the ratio of tricuspid annular plane systolic excursion to PASP (TAPSE\/PASP) (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Trends toward significance were found for percent predicted forced vital capacity (FVC%) (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.074) and catheter-derived PASP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.070). A moderate positive correlation was noted between vasculopathy grade and echocardiographic mPAP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Among all parameters evaluated, the product of TAPSE and FVC% demonstrated the highest discriminative ability for vasculopathy (area under the receiver operating characteristic curve [AUC]\u2009=\u20090.790), followed by FVC% (AUC\u2009=\u20090.689) and TAPSE (AUC\u2009=\u20090.678).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Noninvasive measures\u2014particularly the TAPSE\/PASP ratio and composite indices incorporating FVC%\u2014demonstrate moderate correlation with histopathological evidence of pulmonary vasculopathy in ILD patients living at high altitude. These findings highlight the potential utility of noninvasive tools in the preoperative evaluation of pulmonary vascular disease in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251367283","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:26:59Z","timestamp":1755494819000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-3037","authenticated-orcid":false,"given":"Rafael","family":"Conde-Camacho","sequence":"first","affiliation":[{"name":"Department of Pulmonary Vascular Disease, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"},{"name":"Universidad de La Sabana, Ch\u00eda, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2238","authenticated-orcid":false,"given":"Eduardo","family":"Tuta-Quintero","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad de La Sabana, Ch\u00eda, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-6007","authenticated-orcid":false,"given":"Fabio","family":"Var\u00f3n-Vega","sequence":"additional","affiliation":[{"name":"Department of Critical Care and Lung Transplantation, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Fundaci\u00f3n Cardioinfantil-Instituto de Cardiolog\u00eda, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-7696","authenticated-orcid":false,"given":"Jacqueline","family":"Mugnier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fundaci\u00f3n Cardioinfantil-Instituto de Cardiolog\u00eda, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8837-6653","authenticated-orcid":false,"given":"Libardo","family":"Marmolejo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fundaci\u00f3n Cardioinfantil-Instituto de Cardiolog\u00eda, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-3093","authenticated-orcid":false,"given":"Diego","family":"Severiche","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Vascular Disease, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7574-7913","authenticated-orcid":false,"given":"Luis F","family":"Giraldo-Cadavid","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad de La Sabana, Ch\u00eda, Colombia"},{"name":"Department of Interventional Pulmonology, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2000348"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2020.10.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/00368504251336066"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-021-01696-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2023-220179"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0062-2015"},{"key":"e_1_3_3_9_2","article-title":"Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults","volume":"5","author":"Tsujimoto Y","year":"2022","unstructured":"Tsujimoto Y, Kumasawa J, Shimizu S, et al. 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