{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:27Z","timestamp":1777902027630,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Primary adrenal extranodal natural killer (NK)\/T-cell lymphoma (ENKTL) is exceptionally rare, and it remains unclear whether this subtype of ENKTL exhibits distinct clinicopathological features. This case report describes a later 30s female patient who presented with 6 months of back pain. 18F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) revealed a hypermetabolic left adrenal mass. Histopathology revealed diffuse atypical lymphocytes with necrosis and vascular invasion. Immunohistochemical analysis demonstrated tumor cell positivity for CD3, CD2, CD8, TIA-1, and granzyme B, while being negative for CD5, CD4, CD56, CD20, Pax-5, CD30 and keratin, with a Ki-67 proliferation index of approximately 80%. Chromogenic in situ hybridization showed strong and uniform nuclear positivity of Epstein\u2013Barr virus-encoded RNA (EBER) in the neoplastic population. T-cell receptor rearrangement (TR-\u03b3) was in germline configuration. The final diagnosis of primary adrenal CD56-negative extranodal NK\/T-cell lymphoma was confirmed. Chemotherapy was initiated immediately. But she died within 4 months because of disease progression. Primary adrenal ENKTL appears to be exceedingly rare and might portend a particularly poor prognosis. CD56 negativity and advanced stage could potentially represent key prognostic determinants.<\/jats:p>","DOI":"10.1177\/00368504251368731","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T04:53:16Z","timestamp":1755492796000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary adrenal CD56-negative extranodal NK\/T-cell lymphoma: Case report and literature review"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-3948","authenticated-orcid":false,"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Pathology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Departments of Hematology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Guiqian International Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000889"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04143"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20811"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.10.1386"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-114"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-3019-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014818"},{"key":"e_1_3_3_10_2","first-page":"100223","article-title":"Primary adrenal extranodal NK\/T-cell lymphoma: a case report and literature review","volume":"14","author":"Ichikawa S","year":"2020","unstructured":"Ichikawa S, Saito K, Fukuhara N, et al. Primary adrenal extranodal NK\/T-cell lymphoma: a case report and literature review. 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