{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:08Z","timestamp":1777902068049,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acoustic trauma (AT) is a condition for which no standard treatment currently exists. Platelet-rich plasma (PRP) is a neuroregenerative agent. This prospective experimental study was performed to evaluate the effectiveness of PRP in rats subjected to AT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Baseline auditory brainstem response (ABR) and distortion-product otoacoustic emissions (DPOAE) were measured prior to AT induction and again 3 days afterward. Following this, intratympanic PRP was administered to the treatment group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), while the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) received intratympanic saline. After 3 weeks, ABR and DPOAE tests were repeated and compared with the initial results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the PRP group, significant improvements in DPOAE thresholds at 25,000\u2005Hz and 32,000\u2005Hz were observed between the post-trauma and post-treatment stages. No significant differences were found between baseline and post-treatment measurements. ABR thresholds in the PRP group increased significantly following trauma (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.007) but showed no significant difference compared with baseline after treatment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.615). A statistically significant improvement was observed between post-trauma and post-treatment thresholds (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRP appears to contribute positively to auditory recovery following AT, likely due to its neuroregenerative properties. Nevertheless, further randomised, larger-scale studies are required to substantiate these preliminary findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251368744","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:14:42Z","timestamp":1758892482000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of platelet-rich plasma in experimental acute acoustic trauma"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-1934","authenticated-orcid":false,"given":"Serap","family":"Bulut Cobden","sequence":"first","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunus","family":"Kantekin","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altan","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Alt\u0131parmak","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Erzincan Meng\u00fccek Gazi E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Erzincan, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Amasya Sabuncuo\u011flu \u015eerefeddin E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Amasya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-1755","authenticated-orcid":false,"given":"Ali","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"2342","article-title":"Noise-Induced hearing loss","volume":"154","author":"Le Prell CG","unstructured":"Le Prell CG. 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