{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:01Z","timestamp":1777902061787,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>It is widely accepted that elevated low-density lipoprotein cholesterol (LDL-C) levels are a major risk factor for coronary heart disease (CHD). However, even patients who have achieved LDL-C levels below the currently recommended targets may still have residual risk. Recently, Lipoprotein(a) [Lp(a)] has attracted significant attention as independent causal risk factor for CHD. Nonetheless, the role of Lp(a) in acute coronary syndrome (ACS) patients with type 2 diabetes mellitus (T2DM) who have undergone percutaneous coronary intervention (PCI) and achieved the LDL-C target (\u22641.4 mmol\/L) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 462 ACS patients with comorbid T2DM who underwent PCI, with a median follow-up duration of 27 months post-procedure. The primary endpoint was major adverse cardiovascular events (MACE), defined as all-cause death, recurrent acute myocardial infarction (AMI), ischemic stroke, or hospitalization due to recurrent angina. Based on MACE occurrences, patients were divided into MACE group and non-MACE group. Furthermore, patients were further divided into three groups according to their Lp(a) levels. Kaplan\u2013Meier and Cox regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with MACE had more coronary artery lesions, and the plasma Lp(a) concentrations in the MACE group were significantly higher than in the non-MACE group. The incidence of MACE and recurrent AMI was higher in the Lp(a)\u2009\u2265\u2009180 mg\/dL group compared to the other two groups. Even after multivariate adjustment, Lp(a)\u2009\u2265\u2009180 mg\/dL remained closely associated with an increased risk of MACE (HR 2.82, 95% CI: 1.47\u20135.41,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002) and recurrent AMI (HR 3.71, 95% CI: 1.17\u201311.81,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated Lp(a) levels were strongly associated with poor prognosis in ACS patients with T2DM who underwent PCI.<\/jats:p>\n                  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