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The prognosis for SCLC is typically poor once it recurs and metastasizes after first-line treatment. Although numerous studies have investigated second-line therapies for SCLC, the outcomes have been suboptimal. In this case report, we examined the effectiveness of anlotinib combined with palliative chemoradiotherapy in a patient with second-line treatment of SCLC. The patient achieved a long progression-free survival of 31 months with anlotinib combined with palliative chemoradiotherapy. Anlotinib combined with palliative chemoradiotherapy may offer significant therapeutic benefits as a second-line recurrent or metastatic SCLC.<\/jats:p>","DOI":"10.1177\/00368504251382043","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T15:55:57Z","timestamp":1758556557000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term progression-free survival in a patient with extensive-stage small-cell lung cancer following second-line therapy with anlotinib and palliative chemoradiotherapy: A case report"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-9973","authenticated-orcid":false,"given":"Ning","family":"Zan","sequence":"first","affiliation":[{"name":"Department of oncology and hematology, The People's Hospital of Leshan, Leshan, 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