{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:22Z","timestamp":1790837062657,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The diagnosis of M\u00e9ni\u00e8re's disease (MD) and delayed endolymphatic hydrops (DEH) is challenging due to overlapping symptoms. This study aimed to retrospectively evaluate the diagnostic performance of gadolinium-enhanced delayed inner ear magnetic resonance imaging (MRI) for visualizing endolymphatic hydrops (EH) in patients with MD and DEH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 191 patients with unilateral MD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009164) or DEH (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200927), stratified into definite MD (DMD,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009129), probable MD (PMD,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200935), and DEH subgroups. All patients underwent intratympanic administration of gadolinium followed by 3.0-T MRI using 3D-FLAIR and 3D-real-IR sequences. Clinical data, including pure-tone audiometry (PTA), speech recognition score (SRS), electrocochleography (ECochG), and caloric testing, were analyzed to assess correlations between EH and auditory\u2013vestibular function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EH was detected in 85.2% (23\/27) of clinically diagnosed DEH patients. Detection rates were 96.1% in DMD cases and 28.6% in PMD cases. There was no significant difference in cochlear or vestibular EH between the DMD and DEH groups. However, the DMD group exhibited a significantly higher incidence and severity of EH than the PMD group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). In DMD patients, the degree of EH was positively correlated with PTA, clinical stage, and disease course (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and negatively correlated with SRS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The degree of vestibular EH was also positively correlated with caloric test abnormalities (Spearman's \u03c1\u2009=\u20090.350,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gadolinium-enhanced delayed MRI of the inner ear provides objective evidence of EH and improves the diagnostic accuracy for MD and DEH. Its incorporation into standardized diagnostic protocols may further enhance clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251382441","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:36:13Z","timestamp":1759851373000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Gadolinium-enhanced delayed MRI of inner ear: A valuable diagnostic tool for M\u00e9ni\u00e8re's disease and delayed endolymphatic hydrops: A retrospective cohort study"],"prefix":"10.1177","volume":"108","author":[{"given":"Chengcheng","family":"Liu","sequence":"first","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jing","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Ma","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Guo","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkai","family":"Mei","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Cui","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1460-1961","authenticated-orcid":false,"given":"Lianjun","family":"Lu","sequence":"additional","affiliation":[{"name":"Tangdu Hospital, Fourth Military Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-07099-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1525954"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/app14124985"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003754"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2022.2108141"},{"key":"e_1_3_3_7_2","article-title":"Prognosis of asymptomatic endolymphatic hydrops in healthy volunteers: a five-year cohort study","volume":"9","author":"Kimura T","year":"2024","unstructured":"Kimura T, Kitahara T, Okayasu T, et al. 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Clinical characteristics of patients with dizziness\/vertigo showing a dissociation between caloric and video head impulse test results. J Laryngol Otol 2022; 104: 421\u2013427.","journal-title":"J Laryngol Otol"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2024.101513"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-022-00883-x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-09011-2"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1127008"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.08.027"},{"key":"e_1_3_3_35_2","first-page":"197","article-title":"A systematic review on delayed acquisition of post-gadolinium magnetic resonance imaging in M\u00e9ni\u00e8re's disease: imaging of the endolymphatic spaces","volume":"137","author":"Han A","year":"2022","unstructured":"Han A, Kontorinis G. 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