{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:10Z","timestamp":1777902070943,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Health industry research plan of Gansu Province","award":["GSWSHL2021-023"],"award-info":[{"award-number":["GSWSHL2021-023"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore associations between Life's Essential 8 (LE8) scores of cardiovascular health and chest pain risk in adult in the USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional investigation utilized data from National Health and Nutrition Examination Survey study covering the period between 2005 and 2018. Life's Essential 8 scores were generated for each patient, and correlations between variables were probed with multivariate linear and logistic spline models. The participants are American adults over the age of 20.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study enrolled 15,619 American adults, including 4232 reporting chest pain. Multivariate regression analysis revealed that a 10-point increase in the total LE8 score was associated with a 14% drop in chest pain risk (odds ratio\u2009=\u20090.86, 95%CI: 0.83\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Analysis of each LE8 component revealed that increased dietary, nicotine exposure, sleep quality, BMI, and blood glucose score values were all independently related to decreased chest pain risk (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In subgroup analyses, the LE8 exhibited a stronger protective effect in individuals under 60, those with low income, and those without diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A significant association was found between LE8 scores and chest pain incidence in the US adults. Improvements in diet, smoking cessation, better sleep quality, glycemic control, and weight management may be key modifiable targets in the prevention of chest pain. These findings suggest that the LE8 scoring system may function as a valuable, integrated metric for assessing chest pain risk in clinical and public health contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251383090","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:14:42Z","timestamp":1758892482000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between Life's Essential 8 measures and chest pain amon\n                    <u>g<\/u>\n                    adults in the USA: A cross-sectional study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3911-2671","authenticated-orcid":false,"given":"Runze","family":"Song","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3795-248X","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0731-3118","authenticated-orcid":false,"given":"Si","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of gerontology, Lanzhou university second hospital, Lanzhou, Postal, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9957-5470","authenticated-orcid":false,"given":"Jiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-0492","authenticated-orcid":false,"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines [published correction appears in circulation. 2021 Nov 30;144(22):e455] [published correction appears in circulation. 2023 Dec 12;148(24): e281]","volume":"144","author":"Gulati M","year":"2021","unstructured":"Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines [published correction appears in circulation. 2021 Nov 30;144(22):e455] [published correction appears in circulation. 2023 Dec 12;148(24): e281]. Circulation. 2021; 144: e368\u2013e454.","journal-title":"Circulation"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.066"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-0323"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005716"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2024.01.024"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030764"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad240"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030564"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13405"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062457"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.319290"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115663"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02209-y"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1506884"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.09.004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0397-2"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059595"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.522037"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00307.2020"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3155"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10118"},{"key":"e_1_3_3_25_2","first-page":"29","article-title":"Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy","volume":"48","author":"Deng W","year":"2025","unstructured":"Deng W, Xu Z, Hua T, et al. Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy. Bioact Mater 2025; 48: 29\u201342.","journal-title":"Bioact Mater"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030080"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.08.035"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952075"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab002"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2017.08.002"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-3661"},{"key":"e_1_3_3_32_2","article-title":"CIDEC\/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation","volume":"4","author":"Zhu Q","year":"2024","unstructured":"Zhu Q, Luo D, Li Y, et al. CIDEC\/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation. Life Metab 2024; 4: loae035. Published 2024 Sep 18.","journal-title":"Life Metab"},{"key":"e_1_3_3_33_2","first-page":"418","article-title":"Association of TNF-\u03b1 gene variations with thoracic aortic dissection risk in a Chinese Han population","volume":"35","author":"Du XM","year":"2016","unstructured":"Du XM, Liu LW, Du ZK, et al. Association of TNF-\u03b1 gene variations with thoracic aortic dissection risk in a Chinese Han population. Int Angiol 2016; 35: 418\u2013424.","journal-title":"Int Angiol"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443082"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251383090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251383090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251383090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:18:05Z","timestamp":1777634285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251383090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/00368504251383090"],"URL":"https:\/\/doi.org\/10.1177\/00368504251383090","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"article-number":"00368504251383090"}}