{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:02:04Z","timestamp":1791903724124,"version":"4.3.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jinhua Science and Technology Research Program","award":["2022-3-060"],"award-info":[{"award-number":["2022-3-060"]}]},{"name":"Jinhua Science and Technology Research Program","award":["2023-4-074"],"award-info":[{"award-number":["2023-4-074"]}]},{"name":"Zhejiang Provincial Medical Science Foundation","award":["2024KY435"],"award-info":[{"award-number":["2024KY435"]}]},{"name":"Provincial Key Clinical Specialty of Zhejiang","award":["2024-ZJZK-002"],"award-info":[{"award-number":["2024-ZJZK-002"]}]},{"name":"he Provincial medical and Health Science and Technology Program, provincial and Ministry co-construction project in China","award":["WKJ-ZJ-2303"],"award-info":[{"award-number":["WKJ-ZJ-2303"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the risk factors associated with thrombocytopenia in patients undergoing extracorporeal membrane oxygenation (ECMO) support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 230 patients who received ECMO support during January 2018 to December 2024. Clinical data collected included age, gender, causes of ECMO, medical history, vital signs, laboratory test results, complications and outcomes. The patients were divided into the thrombocytopenia group and the control group based on whether the patient's platelet count was less than 150*10\n                      <jats:sup>9<\/jats:sup>\n                      \/L. The differences in clinical data between the two groups were compared. Moreover, risk factors associated with thrombocytopenia were identified using univariate and multivariate regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, a total of 230 patients undergoing ECMO were involved. The mean age of patients was 52\u2009\u00b1\u20098 years with 119 (51.7%) males and 111 (48.3%) females. The age, sex distribution, reasons for ECMO, previous medical history, temperature, respiration rate, heart rate, mean arterial pressure, white blood cells, hemoglobin, C-reactive protein, platelets, total bilirubin, alanine aminotransferase, aspartate aminotransferase, prothrombin time, activated partial thromboplastin time, blood lactate between two groups showed no statistically significant differences (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u20090.05) while the APACHE II score (24(20,28) vs 21(17,24)) was higher in thrombocytopenia group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The bleeding events were significantly higher (62.4% vs 15.7%), in-hospital survival (49.7% vs 62.9%) was lower, the duration of ICU stay (19(16,23) vs 18 (14,22)) was longer, and more platelet (30(10,40) vs 15 (10,20)) and plasma transfusions (600(400,800) vs 450 (200,600)) in thrombocytopenia group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Logistic regression analysis showed that APACHE II score, rotational speed over the first 48\u2005h, with sepsis, the heparin doseage before ECMO, use of continuous renal replacement therapy (CRRT) and intra-aortic balloon pump (IABP) during ECMO were risk factors associated with thrombocytopenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of thrombocytopenia in patients receiving ECMO is high and may be associated with poor prognosis. Patients with higher APACHE II score, higher rotational speed during the first 48\u2005h, sepsis, higher heparin doseage before ECMO initiation, and the use of CRRT or IABP may at an increased risk of developing thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251385949","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:13:36Z","timestamp":1759943616000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors of thrombocytopenia in adults receiving extracorporeal membrane oxygenation support: A single center retrospective cohort study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3295-0254","authenticated-orcid":false,"given":"Hongjie","family":"Tong","sequence":"first","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yao","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Pan","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Jinjin","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Jiaxing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Jinhua Hospital Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1961707"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13520"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02546-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04612-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06031-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02562-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591231224635"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272577"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_11_2","first-page":"123","article-title":"Incidence, predictors, and prognosis of thrombocytopenia among patients undergoing intra-aortic balloon pumping in the intensive care unit: a propensity score analysis","volume":"18","author":"Tong W","year":"2021","unstructured":"Tong W, Wang JM, Li JY, et al. Incidence, predictors, and prognosis of thrombocytopenia among patients undergoing intra-aortic balloon pumping in the intensive care unit: a propensity score analysis. J Geriatr Cardiol 2021; 18: 123\u2013134.","journal-title":"J Geriatr Cardiol"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07225-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4312-9"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154216"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322752"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591241236139"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.12.009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1905512"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1271319"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1921722"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.19-349"},{"key":"e_1_3_3_22_2","first-page":"322","article-title":"Thrombocytopenia in children and young adults undergoing continuous renal replacement therapy: a WE-ROCK study","author":"Basalely A","unstructured":"Basalely A, Gist KM, Stanski NL, et al. Thrombocytopenia in children and young adults undergoing continuous renal replacement therapy: a WE-ROCK study. Blood Purif 2025; 54: 322\u2013333.","journal-title":"Blood Purif"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323662"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251385949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251385949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251385949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:18:13Z","timestamp":1777634293000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251385949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00368504251385949"],"URL":"https:\/\/doi.org\/10.1177\/00368504251385949","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"00368504251385949"}}