{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:38:27Z","timestamp":1790509107603,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We applied Mendelian Randomization (MR) to investigate potential genetic targets involved in the pathogenesis of COVID-19, aiming to identify causal factors that may contribute to disease susceptibility and severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We aggregated multi-omics quantitative trait loci data and explored the pathogenic targets of COVID-19 using summary data-based Mendelian randomization, colocalization, and MR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified Latent transforming growth factor beta binding protein 2 (LTBP2) and\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -1,3-N-acetylgalactosaminyltransferase (ABO) as primary targets for the risk of severe COVID-19. Elevated levels of LTBP2 (odds ratio (OR): 0.53, 95% CI: 0.39\u20130.70) were associated with reduced risk of severe COVID-19, while ABO (OR: 1.09, 95% CI: 1.06\u20131.11) were associated with increased risk of severe COVID-19. These effects were consistent with the expression of LTBP2 (OR: 0.58, 95% CI: 0.45\u20130.75) and the methylation of ABO (cg07241568: OR: 1.20, 95% CI: 1.14\u20131.26; cg24267699: OR: 1.11, 95% CI: 1.08\u20131.15) regarding the risk of severe COVID-19.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have identified several potential genes related to COVID-19 risks, providing a basis for understanding the pathogenesis of COVID-19 and the development of candidate therapeutic drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251385959","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:48:00Z","timestamp":1760550480000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of COVID-19 susceptibility genes by Mendelian randomization"],"prefix":"10.1177","volume":"108","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Harbin Medical University Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keru","family":"Ma","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shan","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-7533","authenticated-orcid":false,"given":"Guoqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047538"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2021.102058"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-0636-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03065-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020283"},{"key":"e_1_3_2_7_2","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies NM","year":"2018","unstructured":"Davies NM, Holmes MV, Davey Smith G. 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