{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:03Z","timestamp":1777902063343,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the association between systemic inflammatory response syndrome (SIRS) and 30-day mortality in critically ill cirrhosis patients with acute kidney injury (AKI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized the Medical Information Mart for Intensive Care-IV database. Multivariable Cox proportional hazard regression, with covariates selected by Least Absolute Shrinkage and Selection Operator regression, was employed to assess the association. Model performance was evaluated with the Brier score, and the additive predictive value of SIRS to the model for end-stage liver disease (MELD) and sequential organ failure assessment (SOFA) scores was compared using the DeLong test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1797 enrolled patients, the 30-day mortality rate was 38.23% (n\u2009=\u2009687). A higher SIRS was independently associated with increased 30-day mortality (adjusted hazard ratio: 1.31; 95% confidence interval: 1.20\u20131.43). This association remained consistent across subgroups stratified by age, gender, albumin infusion, sepsis, AKI stage, and etiology (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The predictive performance for mortality was significantly improved when SIRS was combined with MELD or SOFA scores compared to each score alone [areas under the curve: SIRS\u2009+\u2009MELD\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      MELD, 0.711\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      0.697; SIRS\u2009+\u2009SOFA\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      SOFA, 0.635\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      0.617].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An elevated SIRS score was associated with a higher risk of short-term mortality in critically ill cirrhosis patients with AKI. As an easily obtainable bedside metric, SIRS represents a valuable tool for identifying high-risk patients, potentially enabling timely clinical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251387229","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:48:32Z","timestamp":1760550512000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of systemic inflammatory response syndrome with 30-day mortality in critically ill cirrhosis patients with acute kidney injury: An analysis of the Medical Information Mart for Intensive Care-IV database"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9672-1688","authenticated-orcid":false,"given":"Jia","family":"Tian","sequence":"first","affiliation":[{"name":"the Second Affiliated Hospital of Harbin Medical University"},{"name":"Department of Nephrology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyi","family":"Du","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5492\/wjccm.v13.i2.91212"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2019.00060"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.043"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2215289"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12467"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.051"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9641-1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0022-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12886"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25328"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.025"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3921-4"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S407202"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035931"},{"key":"e_1_3_3_20_2","first-page":"81","article-title":"Novel predictors of response to therapy with terlipressin and albumin in hepatorenal syndrome-acute kidney injury","volume":"37","author":"Narayanan V","year":"2024","unstructured":"Narayanan V, Devadas K, Sreesh S, et al. 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