{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:03Z","timestamp":1777902063265,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC1712901"],"award-info":[{"award-number":["2021YFC1712901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Project on Clinical Evidence-based Research for the Construction of High-level Traditional Chinese Medicine Hospitals of Wangjing Hospital, China Academy of Chinese Medical Sciences","award":["WJYY-XZKT-2023-21"],"award-info":[{"award-number":["WJYY-XZKT-2023-21"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with high rates of intensive care unit admission and elevated mortality. While urine output (UO) has been demonstrated to predict short-term adverse outcomes in critically ill patients, there is a paucity of research on its prognostic value for in-hospital mortality in AECOPD patients. This study aims to examine the association between UO and in-hospital mortality in AECOPD patients, and to assess its potential as a non-invasive prognostic indicator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study included 938 AECOPD patients from the Medical Information Mart for Intensive Care IV database. Patients were grouped by initial 24-h UO: low UO (\u2264800\u2005mL), moderate UO (800\u20132500\u2005mL, reference), and high UO (\u22652500\u2005mL). Restricted cubic spline regression, receiver operating characteristic curves, Kaplan\u2013Meier (K-M) survival analysis, Cox proportional hazards regression models, subgroup analysis, and mediation analysis evaluated UO's association with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In-hospital mortality was 16.2%. UO showed a U-shaped non-linear association with mortality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for nonlinearity\u2009&lt;\u20090.05), with the lowest risk at 1375\u20134988\u2005mL\/24\u2005h (hazard ratio\n                      <jats:underline>[H.R.]\u2009&lt;\u20091<\/jats:underline>\n                      ). UO showed limited predictive ability as a standalone marker (area under the curve\u2009=\u20090.62), suggesting it should be interpreted alongside other clinical parameters. K-M analysis indicated higher survival in the polyuria group versus oliguria (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). In unadjusted Cox regression, polyuria was associated with a lower risk of mortality (\n                      <jats:underline>H.R.<\/jats:underline>\n                      \u2009=\u20090.51, 95% CI: 0.30\u20130.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.011), whereas oliguria was associated with a higher risk of 28-day mortality (\n                      <jats:underline>H.R.<\/jats:underline>\n                      \u2009=\u20091.67, 95% CI: 1.22\u20132.27,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001). Subgroup analyses were consistent. Glasgow Coma Scale partially mediated 8.68% of the UO-mortality relationship (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A U-shaped association exists between initial 24-h UO and short-term mortality in AECOPD. UO is an important but non-independent prognostic marker, functioning as a surrogate for overall disease severity. Its clinical application requires corroboration with other clinical markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251387235","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T18:36:43Z","timestamp":1761331003000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between urine output and in-hospital mortality among patients with acute exacerbation of chronic obstructive pulmonary disease: A cohort study based on the Medical Information Mart for Intensive Care IV database"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2643-6490","authenticated-orcid":false,"given":"Saimei","family":"Nie","sequence":"first","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjian","family":"Yu","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Su","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00239-2023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01986-y"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-022-00672-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2020.06.007"},{"key":"e_1_3_3_6_2","first-page":"621","article-title":"Hospitalizations for COPD exacerbations: Trends and determinants of death","volume":"12","author":"Molinari N","year":"2015","unstructured":"Molinari N, Briand C, Vachier I, et al. 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