{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:15:41Z","timestamp":1792512941320,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    The RNA N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification, catalyzed by methyltransferase-like 3 (METTL3), is a key epigenetic regulator of oral health and disease. This narrative review positions METTL3 as a dual-function master switch in oral biology. It promotes stem cell-driven regeneration but also drives disease progression. Physiologically, METTL3 enhances the odontogenic\/osteogenic differentiation of dental pulp stem cells (DPSCs). It stabilizes key transcripts (e.g., lncSNHG7, GDF6, STC1) via m\n                    <jats:sup>6<\/jats:sup>\n                    A modification, activating Wnt\/\u03b2-catenin signaling to foster dentinogenesis and pulp vitality\u2014key goals in regenerative endodontics. Conversely, METTL3 dysregulation promotes oral diseases. It impairs osteogenesis in periodontal stem cells (BMSCs\/PDLSCs) via the IGF2BP1\/m\n                    <jats:sup>6<\/jats:sup>\n                    A\/RUNX2 and PI3K\/AKT pathways, worsening bone loss in periodontitis. In oral squamous cell carcinoma (OSCC), METTL3 acts oncogenic. It stabilizes mRNAs like c-Myc, PD-L1, and BMI1 through reader proteins (YTHDF1\/IGF2BPs), driving tumor growth, metastasis, and chemoresistance (e.g., to Cisplatin and Anlotinib). Pharmacological inhibition of METTL3 (e.g., with Allocryptopine or Oxymatrine) shows promise by suppressing OSCC progression and rescuing bone formation. We propose METTL3 as a unifying therapeutic target to advance both regenerative dentistry and precision oncology for oral diseases. Targeting METTL3 epitranscriptomics could transform future oral therapies.\n                  <\/jats:p>","DOI":"10.1177\/00368504251389718","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:07:07Z","timestamp":1761070027000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["METTL3: A dual regulator of oral tissue regeneration and malignancy with therapeutic implications for stem cell therapy and chemoresistance"],"prefix":"10.1177","volume":"108","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Chengdu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1423-1158","authenticated-orcid":false,"given":"Yuanzhong","family":"Liang","sequence":"additional","affiliation":[{"name":"Chengdu Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05829-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.167010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.03.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab378"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0168-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18512-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4180"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02223-x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X16666210215160402"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052269"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010113"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12997"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-02836-z"},{"key":"e_1_3_3_17_2","first-page":"2162","article-title":"Emerging role of epigenetic regulations in periodontitis: a literature review","volume":"14","author":"Huang J","year":"2022","unstructured":"Huang J, Zhou Y. Emerging role of epigenetic regulations in periodontitis: a literature review. 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M(6)A methyltransferase METTL3 promotes oral squamous cell carcinoma progression through enhancement of IGF2BP2-mediated SLC7A11 mRNA stability. Am J Cancer Res 2021; 11: 5282\u20135298.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6149558"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.06.024"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00815-x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14083"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells.11223605"},{"key":"e_1_3_3_44_2","first-page":"5228713","article-title":"Anlotinib suppresses oral squamous cell carcinoma growth and metastasis by targeting the RAS protein to inhibit the PI3K\/Akt signalling pathway","volume":"2021","author":"Lu Y","year":"2021","unstructured":"Lu Y, Lin J, Duan M, et al. Anlotinib suppresses oral squamous cell carcinoma growth and metastasis by targeting the RAS protein to inhibit the PI3K\/Akt signalling pathway. 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