{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:23Z","timestamp":1777902083158,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Yellow Fever (YF) is a vector-borne flavivirus infection that can rapidly evolve into fulminant hepatic failure (FHF), a condition associated with high mortality and severe neurological complications, including intracranial hemorrhage (ICH). Early identification of such complications remains a clinical challenge, especially in critically ill patients where the neurological examination is often limited. We present the case of a 60-year-old male with laboratory-confirmed YF by reverse transcription polymerase chain reaction, who developed ICH during the course of his illness. The implementation of a multimodal neuromonitoring approach\u2014including near-infrared spectroscopy, transcranial Doppler, and jugular venous oxygen saturation\u2014enabled the early detection of cerebral hemodynamic and perfusion changes suggestive of intracranial pathology. Despite the timely recognition of ICH, the patient's rapidly deteriorating coagulopathy, driven by FHF, precluded successful intervention, culminating in brain death. This case highlights the value of integrating advanced neuromonitoring modalities in the intensive care setting to enable prompt identification of life-threatening neurological complications. Although not sufficient to alter the fatal trajectory in this instance, early neuromonitoring may offer a critical window for therapeutic decision-making in patients with severe YF. Future research is needed to define standardized neuromonitoring protocols and to evaluate their impact on outcomes in this high-risk population.<\/jats:p>","DOI":"10.1177\/00368504251392608","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:05:09Z","timestamp":1762794309000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early detection of intracranial hemorrhage in Yellow Fever utilizing multimodal neuromonitoring: A case report"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-9127","authenticated-orcid":false,"given":"Jeison Andr\u00e9s","family":"Morales-Olivera","sequence":"first","affiliation":[{"name":"Cl\u00ednica Keralty"},{"name":"School of Medicine, Faculty of Health Sciences, Universidad del Tolima, Ibagu\u00e9, Colombia"},{"name":"Hospital Federico Lleras Acosta"},{"name":"Facultad de Medicina, Doctorado en Ciencias Cl\u00ednicas, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"},{"name":"School of Medicine, Corporaci\u00f3n Instituci\u00f3n Universitaria Salud Colombia, Ibagu\u00e9, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex Juli\u00e1n","family":"Forero-Delgadillo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Keralty"},{"name":"School of Medicine, Faculty of Health Sciences, Universidad del Tolima, Ibagu\u00e9, Colombia"},{"name":"Hospital Federico Lleras Acosta"},{"name":"School of Medicine, Corporaci\u00f3n Instituci\u00f3n Universitaria Salud Colombia, Ibagu\u00e9, Colombia"},{"name":"Ph.D. Student in Biosciences, School of Engineering, University of La Sabana, Cundinamarca, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n Fernando","family":"Celis-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Keralty"},{"name":"School of Medicine, Faculty of Health Sciences, Universidad del Tolima, Ibagu\u00e9, Colombia"},{"name":"Hospital Federico Lleras Acosta"},{"name":"School of Medicine, Corporaci\u00f3n Instituci\u00f3n Universitaria Salud Colombia, Ibagu\u00e9, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Adolfo","family":"Gonz\u00e1lez-Varona","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Keralty"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Quintero-Altare","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Robayo-Amortegui","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Doctorado en Ciencias Cl\u00ednicas, Universidad de La Sabana, Ch\u00eda, Cundinamarca, Colombia"},{"name":"Fundaci\u00f3n Cl\u00ednica Shaio"},{"name":"School of Medicine, Universidad de La Sabana, Ch\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Epidemiological Alert Yellow fever in the Americas Region [Internet]. 2025. Available from: www.paho.org"},{"key":"e_1_3_3_3_2","first-page":"101144","article-title":"Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever","volume":"48","author":"Forero-Delgadillo AJ","year":"2025","unstructured":"Forero-Delgadillo AJ, Morales-Olivera JA, Celis-Guzm\u00e1n JF, et al. Colombian consensus on the care of critically ill patients with suspected or confirmed severe yellow fever. Lancet Reg Health Am 2025; 48: 101144.","journal-title":"Lancet Reg Health Am"},{"key":"e_1_3_3_4_2","first-page":"434","article-title":"Yellow fever: global impact, epidemiology, pathogenesis, and integrated prevention approaches","volume":"32","author":"Srivastava S","year":"2024","unstructured":"Srivastava S, Dhoundiyal S, Kumar S, et al. Yellow fever: global impact, epidemiology, pathogenesis, and integrated prevention approaches. Infez Med 2024; 32: 434\u2013450.","journal-title":"Infez Med"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40794-022-00187-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taz040"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.039"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.04.013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.10.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005400050020"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00377-X"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251392608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251392608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251392608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:18:39Z","timestamp":1777634319000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251392608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00368504251392608"],"URL":"https:\/\/doi.org\/10.1177\/00368504251392608","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"00368504251392608"}}