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GBM patients exhibit poor survival outcomes following standard treatment, with drug resistance playing a critical role in disease progression. This study aimed to evaluate the effects of valsartan, a renin\u2212angiotensin system inhibitor, on GBM cell lines with and without temozolomide (TMZ) resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TMZ-resistant GBM clones were established by repeatedly exposing LN229 and GBM8401 human glioma cells to high doses of TMZ, followed by selective culture of the surviving populations. Tumorigenic potential was assessed using viability, sphere formation, invasion, and apoptosis assays. Gene expression was examined by sequencing and validated by quantitative polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Valsartan reduced the proportion of viable GBM cells regardless of TMZ sensitivity. Flow cytometry and western blotting revealed increased apoptosis in GBM following valsartan treatment. RNA sequencing revealed that valsartan regulates the cell cycle and induces G1-phase arrest, as evidenced by cell cycle flow cytometry. Moreover, APLN, an angiogenesis-related gene, was identified as a potential downstream target whose expression is significantly inhibited by valsartan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed that valsartan is a novel strategy for treating gliomas with drug resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251398885","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T17:58:51Z","timestamp":1764007131000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of valsartan in overcoming chemoresistance in human glioblastoma"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2789-1674","authenticated-orcid":false,"given":"Jia-Rong","family":"Hu","sequence":"first","affiliation":[{"name":"National Defense Medical University"},{"name":"Department of Biochemistry, National Defense Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Kao","sequence":"additional","affiliation":[{"name":"Taipei City Hospital Zhongxing Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Lung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, National Defense Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Chi","family":"Yang","sequence":"additional","affiliation":[{"name":"National Defense Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-1408","authenticated-orcid":false,"given":"Chia-Kuang","family":"Tsai","sequence":"additional","affiliation":[{"name":"National Defense Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dueng-Yuan","family":"Hueng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, National Defense Medical University, Taipei, Taiwan"},{"name":"Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac071"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21693"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa106"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.08.011"},{"key":"e_1_3_3_6_2","first-page":"17","article-title":"Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review","volume":"4","author":"Singh N","year":"2021","unstructured":"Singh N, Miner A, Hennis L, et al. 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