{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:03:27Z","timestamp":1787018607637,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Fluid management in critically ill obese patients is challenging due to the risk of fluid overload when using standard weight-based formulas. This study aims to evaluate the association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury (AKI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included elderly obese critically ill patients with AKI admitted to a tertiary care ICU between January 2020 and December 2022. AKI was diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Fluid overload was defined as body weight-adjusted fluid balance &gt;10%. The primary outcome was 90-day all-cause mortality. Statistical analyses included Kaplan\u2013Meier survival curves and multivariate Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 539 elderly obese critically ill patients with AKI were included, of whom 244 (45.3%) developed fluid overload. During the 90-day follow-up, 209 patients (38.8%) died. Patients with fluid overload had significantly higher 90-day mortality compared to those without fluid overload (50.4% vs. 29.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Kaplan\u2013Meier analysis showed a higher mortality risk for fluid-overloaded patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Multivariate Cox regression indicated that fluid overload (HR\u2009=\u20092.04, 95% CI: 1.24\u20133.36,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and SOFA score (HR\u2009=\u20091.13, 95% CI: 1.04\u20131.22,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01) were independent predictors of increased mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fluid overload is significantly associated with increased 90-day mortality in elderly obese critically ill patients with AKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251404080","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T18:30:54Z","timestamp":1767724254000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury: A retrospective cohort study"],"prefix":"10.1177","volume":"109","author":[{"given":"Jiesheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Pu\u2019er People's Hospital, Pu\u2019er, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8748-9642","authenticated-orcid":false,"given":"Junhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Pu\u2019er People's Hospital, Pu\u2019er, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06454-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.153"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01645-3"},{"key":"e_1_3_3_5_2","unstructured":"Goyal A Daneshpajouhnejad P Hashmi MF et al. Acute Kidney Injury. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Parnaz Daneshpajouhnejad declares no relevant financial relationships with ineligible companies. Disclosure: Muhammad Hashmi declares no relevant financial relationships with ineligible companies. Disclosure: Khalid Bashir declares no relevant financial relationships with ineligible companies 2025."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae146"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000446265"},{"key":"e_1_3_3_8_2","unstructured":"Castera MR Borhade MB. Fluid Management. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Mahesh Borhade declares no relevant financial relationships with ineligible companies. 2024."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101237"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0323-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15238"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199808000-00012"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2663-7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-020-00496-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201504-187OC"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.159"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318246b9c6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.747732"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1506331"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018819897527"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23401"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251404080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251404080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251404080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:19:09Z","timestamp":1777634349000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251404080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/00368504251404080"],"URL":"https:\/\/doi.org\/10.1177\/00368504251404080","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"00368504251404080"}}