{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:48Z","timestamp":1777902108615,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Criteria to differentiate pediatric knee joint effusion remained inexpedient. This study aimed to establish a prediction rule to distinguish infection from other inflammatory arthritis in children presenting with knee pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An ambi-directional cohort was conducted at the university hospital from 1999 to 2021 by including children aged \u2264 15 years with knee pain\/swelling, complete physical examination, knee imaging, laboratory, and\/or synovial fluid analysis. Contaminated synovial fluid culture and incomplete medical records were excluded. Diagnosis of septic knee (positive joint fluid culture or synovial white blood cell counts\u2009&gt;\u200950,000 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) or other inflammatory joints were retrieved. Baseline characteristics, physical examination, and laboratory investigations were analyzed. The probability of septic arthritis was calculated based on numbers of predictors from the final model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 48 patients (average age 7.0\u2009\u00b1\u20094.0 years, and 24 (50%) unilateral involvement), the incidence of septic knee was 9 patients (18.8%), and 39 patients with other inflammatory arthritis. Multivariate logistic regression identified three predictors: unable to bear weight, ballottement, and erythrocyte sedimentation rate (ESR) \u2265 75\u2005mm\/h (adjusted odds ratio (OR) 36.2, 19.4, and 31.9, respectively, the model chi-square\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001, with area under receiver operating characteristic curve\u2009=\u20090.9188). Estimated probability of having septic knee according to 1, 2, and 3 predictors was 27.3% (95% confidence interval (CI) 13.3\u201345.5%), 61.5% (95% CI 31.6\u201386.1%), and 100% (95% CI 15.8\u2013100%), respectively. The optimal cutoff value from sum of estimated ORs was \u2265 51.29 (at least 2 predictors) with sensitivity 88.89%, specificity 87.18%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical predictive factors of septic knee in children may be practically determined by unable to bear weight, ballottement, and ESR at least 75\u2005mm\/h. The probability of septic knee increases, especially for positive 2\u20133 factors. Further large studies would benefit for external validating this prediction rule.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251407178","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:15:13Z","timestamp":1766423713000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical predictive factors for septic arthritis of the knee in children: A cohort study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6872-5436","authenticated-orcid":false,"given":"Kantapon","family":"Khoployklang","sequence":"first","affiliation":[{"name":"Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-1008","authenticated-orcid":false,"given":"Thira","family":"Woratanarat","sequence":"additional","affiliation":[{"name":"Chulalongkorn University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-9711","authenticated-orcid":false,"given":"Soamarat","family":"Vilaiyuk","sequence":"additional","affiliation":[{"name":"Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-8079","authenticated-orcid":false,"given":"Chanika","family":"Angsanuntsukh","sequence":"additional","affiliation":[{"name":"Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-0998","authenticated-orcid":false,"given":"Patarawan","family":"Woratanarat","sequence":"additional","affiliation":[{"name":"Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fms044"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S115429"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2020.02.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-021-00307-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehmc.2014.06.009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01267.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.2.160027"},{"key":"e_1_3_3_9_2","first-page":"379","article-title":"Polyarticular juvenile idiopathic arthritis - epidemiology and management approaches","volume":"6","author":"Oberle EJ","year":"2014","unstructured":"Oberle EJ, Harris JG, Verbsky JW. Polyarticular juvenile idiopathic arthritis - epidemiology and management approaches. Clin Epidemiol 2014; 6: 379\u2013393. https:\/\/www.dovepress.com\/getfile.php?fileID=22175","journal-title":"Clin Epidemiol"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/18632521221106383"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.14.01331"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00216"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199912000-00002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200408000-00005"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000001377"},{"key":"e_1_3_3_16_2","first-page":"71","article-title":"Genetic and immunological evidences of Borrelia burgdorferi in dog in Thailand","volume":"47","author":"Sthitmatee N","year":"2016","unstructured":"Sthitmatee N, Jinawan W, Jaisan N, et al. Genetic and immunological evidences of Borrelia burgdorferi in dog in Thailand. Southeast Asian J Trop Med Public Health 2016; 47: 71\u201377.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.740285"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-3-424"},{"key":"e_1_3_3_20_2","first-page":"32","article-title":"International statistical classification of diseases and related health problems","volume":"41","author":"Br\u00e4mer GR","year":"1988","unstructured":"Br\u00e4mer GR. International statistical classification of diseases and related health problems. Tenth Revision. World Health Stat Q 1988; 41: 32\u201336.","journal-title":"Tenth Revision. World Health Stat Q"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-011-1458-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"e_1_3_3_23_2","first-page":"390","article-title":"International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390\u2013392.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0936-1"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1302\/1863-2548.12.180004"},{"key":"e_1_3_3_27_2","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley RD","year":"2020","unstructured":"Riley RD, Ensor J, Snell KIE, et al. Calculating the sample size required for developing a clinical prediction model. Br Med J 2020; 368: m441.","journal-title":"Br Med J"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.08.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-014-0549-4"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00028-14"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002455"},{"key":"e_1_3_3_32_2","article-title":"Lyme arthritis in the pediatric knee: clinical and magnetic resonance imaging differentiators","volume":"7","author":"Yen YM","year":"2022","unstructured":"Yen YM, Sanborn RM, Donohue K, et al. Lyme arthritis in the pediatric knee: clinical and magnetic resonance imaging differentiators. JB JS Open Access 2022; 7.","journal-title":"JB JS Open Access"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2024.102696"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251407178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251407178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251407178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:19:18Z","timestamp":1777634358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251407178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/00368504251407178"],"URL":"https:\/\/doi.org\/10.1177\/00368504251407178","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"00368504251407178"}}