{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:31Z","timestamp":1777902091451,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chongqing Science and Health Joint Medical Research Youth Project","award":["2025QNXM015"],"award-info":[{"award-number":["2025QNXM015"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To validate a serial multimodal ultrasound (MMUS) protocol for assessing dynamic tibialis anterior changes in detecting intensive care unit-acquired weakness (ICUAW) and to develop a diagnostic algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective cohort of 97 high-risk adults (mean age 60.7\u00b113.7 years; 73.2% male; SOFA score \u22658 for \u22653 days), MMUS quantified structural (thickness, echogenicity), hemodynamic (perfusion grade, peak systolic velocity [PSV]), and mechanical (elastic modulus) parameters of the tibialis anterior at ICU admission (Day 1) and Day 7. ICUAW was diagnosed per American Thoracic Society guidelines. Serum biomarkers (IL-6, PCT, CRP) were correlated with sonographic changes. Diagnostic models were constructed using binary logistic regression and evaluated by ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      31 patients (32.0%) developed ICUAW. By Day 7, the ICUAW group showed greater structural deterioration (echogenicity progression: 54.8% vs. 16.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), hemodynamic changes (PSV: 7.60 \u00b1 1.72 vs. 6.35 \u00b1 1.78 cm\/s,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and faster stiffness increase (elastic modulus rate: 14.1\u00b112.3% vs. 5.4\u00b16.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Day 7 PSV correlated with IL-6 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.59), PCT (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.50), and CRP (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.68) (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). A 7-parameter model achieved an AUC of 0.917 (95%CI: 0.857-0.978) with an NPV of 92.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dynamic MMUS captures ICUAW pathophysiology. The proposed algorithm shows potential as a non-invasive bedside tool for early risk stratification, pending multicenter validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251409993","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:06:45Z","timestamp":1768810005000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic tibialis anterior ultrasound monitoring reveals a multimodal ultrasound signature for intensive care unit-acquired weakness: A prospective cohort study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5805-2013","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2002-3562","authenticated-orcid":false,"given":"Jingjing","family":"Yin","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2341-0075","authenticated-orcid":false,"given":"Xiaoling","family":"Hu","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-7493","authenticated-orcid":false,"given":"Yuxia","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8231-8247","authenticated-orcid":false,"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5342-453X","authenticated-orcid":false,"given":"Yan","family":"Du","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1136-1257","authenticated-orcid":false,"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217840"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05927-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2807-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002208"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12620"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0628-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b6ef67"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1829OC"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0993-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142430"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2011ST"},{"key":"e_1_3_3_13_2","first-page":"45","article-title":"Technical standards for shear wave elastography in neuromuscular diagnostics: an international consensus","volume":"237","author":"Smith R","year":"2023","unstructured":"Smith R, Jones AB, Johnson CD, et al. 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