{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:10:48Z","timestamp":1788631848124,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"This research was supported by the 2018 Municipal Science and Technology Bureau Key Research and Developmen","award":["No. KC18189"],"award-info":[{"award-number":["No. KC18189"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis remains a primary contributor to mortality among critically ill individuals, and the assessment of vascular stiffness, indicated by estimated pulse wave velocity (ePWV), could offer insights into patient outcomes. This retrospective cohort study examines the correlation between ePWV levels and all-cause mortality in individuals with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 22,166 sepsis patients from the MIMIC-IV database were included. Cox regression analysis, restricted cubic spline (RCS) analysis, and subgroup analyses were conducted to evaluate the association between ePWV and 30-day and 365-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 30-day and 365-day mortality rates were 18.28% and 32.93%, respectively. Compared to the first quartile (Q1), patients in the highest ePWV quartile (Q4) had a 92% higher risk of 30-day mortality (HR: 1.92, 95% CI: 1.73\u20132.13,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and an 75% higher risk of 365-day mortality (HR: 1.75, 95% CI: 1.62\u20131.89,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in adjusted models. RCS analysis identified a nonlinear association between ePWV and mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for non-linearity &lt; 0.001) with inflection points at 9.04 m\/s for 30-day mortality and 10.81\u2005m\/s for 365-day mortality. The nomogram model demonstrated good performance in predicting both 30-day and 365-day mortality, with area under the curve values of 0.736 and 0.775 in the training set, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that higher ePWV is significantly associated with increased short- and long-term mortality risk in critically ill sepsis patients, with evidence of a nonlinear relationship. ePWV may serve as a valuable prognostic marker to identify sepsis patients at higher risk of mortality in the ICU.<\/jats:p>\n                  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Shandong, Jining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ye","sequence":"additional","affiliation":[{"name":"The Xuzhou Clinical College of Xuzhou Medical University"},{"name":"Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Li","sequence":"additional","affiliation":[{"name":"The Xuzhou Clinical College of Xuzhou Medical University"},{"name":"Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tang","sequence":"additional","affiliation":[{"name":"The Xuzhou Clinical College of Xuzhou Medical University"},{"name":"Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, 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