{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:41:51Z","timestamp":1777902111255,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ganzhou \"Science and Technology and National Regional Medical Center\" Joint Program","award":["2022-YB1276"],"award-info":[{"award-number":["2022-YB1276"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a major global health burden due to risks of cirrhosis and liver cancer; however, the relationship between MAFLD and weight-adjusted-waist index (WWI) remains unclear. Our study aims to clarify this relationship and identify potential clinical predictors for MAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population-based cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132010 and 2015\u20132018. Multivariable logistic regression and Restricted Cubic Splines (RCS) was employed to examine the nonlinear association between WWI and MAFLD. Following this, a subgroup analysis was performed to detect any variations and ensure the robustness of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 17,930 participants aged \u2265 18 years, with a mean age of 45.54 years and 48.43% males. The sample was comprised of 44.36% Non-Hispanic White, 20.69% Mexican American, 19.55% Non-Hispanic Black, 8.00% Other Hispanic, and 7.41% Other\/Multi-Racial individuals. Among them, 5850 individuals were diagnosed with MAFLD. The study found a statistically significant association between WWI and MAFLD (odds ratio (OR)\u2009=\u20094.35, 95% confidence interval [95% CI]: 4.08\u20134.63), which remained significant even after adjusting for all relevant factors (OR\u2009=\u20092.73, 95% CI: 2.48\u20133.01). The RCS analysis revealed a significant nonlinear relationship between WWI and MAFLD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Subgroup analysis indicated that WWI remained positively correlated with MAFLD, but no significant interaction was observed (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -interaction &gt; 0.05)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WWI is a significant predictor of MAFLD, suggesting its potential as a simple, non-invasive screening tool for the occurrence of MAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261420942","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:49:30Z","timestamp":1770140970000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The weight-adjusted-waist index is positively associated with metabolic dysfunction-associated fatty liver disease in US adults: A cross-sectional NHANES Study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2797-4144","authenticated-orcid":false,"given":"Pingping","family":"Liu","sequence":"first","affiliation":[{"name":"Ganzhou People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chongqing Emergency Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daochong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huichang County People's Hospital, Ganzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Li","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Quannan County General Hospital, Ganzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.01.029"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317593"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29489"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2525"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_3_4_9_2","first-page":"16","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li M","year":"2022","unstructured":"Li M, Chi X, Wang Y, et al. 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