{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:43:20Z","timestamp":1793105000701,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0200200"],"award-info":[{"award-number":["2021ZD0200200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis, caused by a dysregulated host response to infection, is a life-threatening condition linked to nearly one-fifth of deaths worldwide. As a biomarker of myocardial stress, N-terminal pro B-type natriuretic peptide (NT-proBNP) has gained attention for its potential association with clinical outcomes in sepsis patients. This study investigated its association with short- and long-term mortality in sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational cohort study utilized data from the Medical Information Mart for Intensive Care IV database. Sepsis patients on their first intensive care unit admission with NT-proBNP measured within 24\u2005h were categorized into four groups based on their natural log-transformed levels. The primary endpoint was 30-day all-cause mortality (ACM), with secondary endpoints of 90-day and 1-year ACM. Cox models, Kaplan\u2013Meier curves, restricted cubic splines (RCS), and subgroup analyses were performed to assess the relationship between log(NT-proBNP) and 30-day, 90-day, and 1-year ACM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort consisted of 1237 patients, with 54.41% male. The 30-day, 90-day, and 1-year ACM rates were 27.41%, 29.99%, and 31.69%, respectively. Multivariate Cox analysis showed that log(NT-proBNP) was independently associated with higher risks of 30-day ACM (hazard ratio[HR] 1.12 [95% confidence interval (CI) 1.03\u20131.22];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.01), 90-day ACM (HR 1.12 [95% CI 1.03\u20131.22];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.005), and 1-year ACM (HR 1.11 [95% CI 1.03\u20131.20];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.007). These associations remained robust in sensitivity analyses. The RCS curves demonstrated a linear increase in ACM risk as log(NT-proBNP) levels rose. Subgroup analyses confirmed these associations across different patient groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated log(NT-proBNP) in critically ill sepsis patients are significantly and independently associated with higher 30-day, 90-day, and 1-year ACM, suggesting that NT-proBNP may serve as a valuable risk marker for both short- and long-term mortality in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261425535","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:31:56Z","timestamp":1771522316000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between N-terminal pro B-type natriuretic peptide and short- and long-term all-cause mortality in critically ill patients with sepsis: A retrospective study based on the Medical Information Mart for Intensive Care IV database"],"prefix":"10.1177","volume":"109","author":[{"given":"Anke","family":"Shi","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuai","family":"Ai","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2456-8254","authenticated-orcid":false,"given":"Jieqiong","family":"Yu","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpeng","family":"Hu","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-0051","authenticated-orcid":false,"given":"Shengtao","family":"Yan","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006541"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.05.014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3036"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31818635b6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000261893.72811.0F"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61888-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.11.013"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-019-01244-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79843-5"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01899-x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_3_2_17_2","unstructured":"DecisionLinnc Core Team. DecisionLinnc. 1.0. https:\/\/www.statsape.com\/. 2023."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.11.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-314173"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032254"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029593"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031453"},{"key":"e_1_3_2_23_2","first-page":"180","article-title":"Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome","volume":"31","author":"Valero Cifuentes S","year":"2019","unstructured":"Valero Cifuentes S, Garc\u00eda Villalba E, Alcaraz Garc\u00eda A, et al. Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome. Emergencias 2019; 31: 180\u2013184.","journal-title":"Emergencias"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2095"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2025.2467339"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1910-0"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.472050"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.07.009"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2505-7"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00492-2"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3748-7"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.007"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002851"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000114827.93410.D8"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000162561.82012.E9"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2023-0605"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.07.013"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2005"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006570"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2018.04.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05351-5"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00279-2"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.062"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1525-9"},{"key":"e_1_3_2_45_2","article-title":"Female-specific association of plasma N-terminal pro-brain natriuretic peptide with organ dysfunction and prognosis in sepsis: a retrospective study","volume":"3","author":"Yin S","year":"2021","unstructured":"Yin S, Zhang Y, Guo Y, et al. Female-specific association of plasma N-terminal pro-brain natriuretic peptide with organ dysfunction and prognosis in sepsis: a retrospective study. Crit Care Explor 2021; 3: e0392.","journal-title":"Crit Care Explor"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261425535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504261425535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261425535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:20:07Z","timestamp":1777634407000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504261425535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/00368504261425535"],"URL":"https:\/\/doi.org\/10.1177\/00368504261425535","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"00368504261425535"}}