{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:06:29Z","timestamp":1779188789739,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pulmonary-to-aortic diameter ratio (P\/A) correlates with pulmonary hypertension (PH), which is linked to adverse outcomes. Our aim was to evaluate the impact of the P\/A ratio, measured using computed tomography (CT), on adverse postoperative outcomes in patients undergoing transcatheter aortic valve implantation (TAVI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 387 patients with aortic valve disease who underwent TAVI between January 2018 and June 2024. The clinical endpoint was the composite outcome of all-cause mortality and postoperative hospitalization for heart failure. The cut-off value for the P\/A ratio was obtained by analyzing the receiver operating characteristic (ROC) curve. Cox proportional hazards models were used to examine the association between the P\/A ratio and the composite outcome, with subsequent subgroup and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up time was 19 months [interquartile range (IQR): 1.00\u201359.0], and a composite outcome occurred in 14% of patients in this study. A P\/A ratio of 0.84 was identified as the optimal cut-off value. Compared with the low P\/A group, the high P\/A group had a higher proportion of females and patients with diabetes, higher triglyceride levels, and higher systolic pulmonary artery pressure (sPAP) levels. Multivariable Cox analysis confirmed that a high P\/A ratio [hazard ratio (HR): 1.96, 95% confidence interval (CI): 1.03\u20133.72; p\u2009=\u20090.04] was associated with the composite outcome. Subgroup and sensitivity analyses yielded consistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The P\/A ratio measured using CT may serve as a novel prognostic factor in patients undergoing TAVI. A high P\/A ratio (\u2265 0.84) is an independent risk factor for the composite outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261431852","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:49:05Z","timestamp":1773226145000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of pulmonary-artery-to-aorta ratio on clinical outcomes in patients undergoing transcatheter aortic valve implantation: A retrospective study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-9217","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 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