{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:43:59Z","timestamp":1788835439464,"version":"build-2803163510"},"reference-count":67,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis-induced coagulopathy (SIC) is a life-threatening complication that significantly impacts patient prognosis. This systematic review and meta-analysis aimed to evaluate clinical and biological indicators associated with the development of SIC to facilitate early risk identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched nine databases for studies reporting predictive factors for SIC. Data were pooled using random-effects or fixed-effects models as appropriate. Methodological quality was assessed using the Newcastle-Ottawa Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 34 studies involving 37,459 patients were included. Meta-analysis revealed that several markers showed a significant association with SIC. Glycocalyx degradation emerged as a strong predictor (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u200911.85, 95% CI: 8.59\u201316.34). Other associated markers included reduced Fibrinogen (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20094.35, 95% CI: 2.47\u20137.69), Albumin (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20092.5, 95% CI: 1.82\u20133.45), Neutrophil Extracellular Traps (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20092.4, 95% CI: 1.81\u20133.19), increased circulating Microparticles (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20091.61, 95% CI: 1.33\u20131.95), elevated Lactate(\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20091.18, 95% CI: 1.13\u20131.23) and Thrombomodulin (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      \u2009=\u20091.10, 95% CI: 0.97\u20131.26), Procalcitonin, APACHE II score and C-reactive protein were also demonstrated predictive value for SIC occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings identify multiple biological and clinical predictors associated with SIC. However, these results should be interpreted as statistical associations rather than direct causal links. These markers may assist clinicians in early recognition of high-risk patients, though further prospective trials are needed to confirm their clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>This study was registered on the PROSPERO (CRD420250653820).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261435291","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:01:55Z","timestamp":1775476915000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Biomarkers and clinical factors associated with sepsis-induced coagulopathy: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-8933","authenticated-orcid":false,"given":"Wei","family":"You","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-2831","authenticated-orcid":false,"given":"Xiaoyu","family":"Fan","sequence":"additional","affiliation":[{"name":"General surgery Department, Zigong Fourth People's Hospital, Zigong, Sichuan, China"},{"name":"Institute of Medical Big Data, Zigong Academy of Artificial Intelligence and Big Data for Medical Science, Zigong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-4295","authenticated-orcid":false,"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Medical Big Data, Zigong Academy of Artificial Intelligence and Big Data for Medical Science, Zigong, Sichuan, China"},{"name":"Emergency Department, Zigong Fourth People's Hospital, Zigong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-515X","authenticated-orcid":false,"given":"Cheng","family":"Lei","sequence":"additional","affiliation":[{"name":"Affiliated Cancer Hospital of University of Electronic Science and Technology of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-6926","authenticated-orcid":false,"given":"Yanli","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.02.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002668"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60446-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S504184"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.863846"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1756300"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000755"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01093-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2112"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03152-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676610"},{"key":"e_1_3_3_15_2","first-page":"0997","article-title":"Sepsis-Induced endothelial barrier dysfunction: mechanisms, pathology, and therapeutic advances","volume":"8","author":"Wang R","year":"2025","unstructured":"Wang R, et al. 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