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Although transfusion-transmitted infections remain rarely documented, donations harbouring high-titre, undetected virus could still breach current pathogen-reduction processes and pose a potential threat to the safety of blood and blood products. To evaluate local risk, this study first determines the immunoglobulin G (IgG) seroprevalence of B19V and its geographic distribution among voluntary blood donors in Shaanxi Province.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, from August to December 2024, an enzyme-linked immunosorbent assay was used to detect the IgG antibody against B19V in sampled batches of qualified blood samples from five municipal central blood stations in Shaanxi Province, and the distribution characteristics of samples were analysed from multiple perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Shaanxi Province, the B19V IgG antibody positivity rate was 24.95% (533 out of 2136), and increased with age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Positive cases showed significant spatial clustering (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a higher number of positive cases in Central Shaanxi and a lower number of positive cases in Northern and Southern Shaanxi. The infection risks were significantly different between northern and southern regions (odds ratio [OR]: 0.592, 95% confidence interval [CI]: 0.448\u20130.782,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared to type A blood, individuals with type B blood have a lower risk of previous infection (OR: 0.718, 95% CI: 0.549\u20130.940,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The previous infection rate of B19V is high among blood donors in Shaanxi Province, influenced by age, blood type, and geography. Given that B19V screening is not yet part of routine donor testing in China, we recommend that blood or blood components intended for immunocompromised, high-risk recipients be tested for B19V before transfusion, so as to reduce the risk of transfusion-transmitted infection in an economical and efficient manner. Future studies should focus on the long-term dynamics of B19V infection and the effectiveness of screening programs in reducing transmission risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261436108","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:40:01Z","timestamp":1773927601000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence and spatial distribution of immunoglobulin (IgG) antibodies against human parvovirus B19 in voluntary blood donors from Shaanxi Province, China: A cross-sectional study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6335-913X","authenticated-orcid":false,"given":"Boya","family":"Zhao","sequence":"first","affiliation":[{"name":"Shaanxi University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7301-9318","authenticated-orcid":false,"given":"Xiaoyue","family":"Chu","sequence":"additional","affiliation":[{"name":"Shaanxi Blood Center, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0607-8833","authenticated-orcid":false,"given":"Hailong","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi\u2019an Center for Disease Control and Prevention, Xi'an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Jin","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hanzhong Central Blood Station, Hanzhong, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongheng","family":"Pan","sequence":"additional","affiliation":[{"name":"An\u2019kang Central Blood Station, An\u2019kang, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Yan\u2019an Central Blood Station, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi Blood Center, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanshi","family":"Gong","sequence":"additional","affiliation":[{"name":"Shaanxi Blood Center, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Sun","sequence":"additional","affiliation":[{"name":"Yan\u2019an Central Blood Station, Yan\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng","family":"Pan","sequence":"additional","affiliation":[{"name":"An\u2019kang Central Blood Station, An\u2019kang, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-8766","authenticated-orcid":false,"given":"Chaofeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Shaanxi University of Chinese Medicine"},{"name":"Shaanxi Blood Center, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"879","article-title":"Advances in molecular biology research on human parvovirus B19","volume":"36","author":"Dong YM","year":"2020","unstructured":"Dong YM, Li JJ, Xu P, et al. 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