{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:00:26Z","timestamp":1782849626988,"version":"3.54.5"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jiangsu Funding Program for Excellent Postdoctoral","award":["2025ZB004"],"award-info":[{"award-number":["2025ZB004"]}]},{"name":"Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program","award":["MS2025046"],"award-info":[{"award-number":["MS2025046"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500834"],"award-info":[{"award-number":["82500834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between different classes of hypoglycemic agents and the occurrence of contrast-induced acute kidney injury (CIAKI) in patients with type 2 diabetes mellitus (T2DM) undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 2082 patients with T2DM who underwent CAG or PCI at two tertiary hospitals between January 2020 and December 2022. Patients were categorized into CIAKI and non-CIAKI groups, and baseline characteristics and short-term in-hospital outcomes were compared. The effects of sodium\u2013glucose cotransporter-2 inhibitors (SGLT2i) use and other classes of glucose-lowering agents on the incidence of CIAKI were evaluated. Multivariable logistic regression analysis was performed to identify factors associated with the occurrence of CIAKI. Propensity score matching was further applied to assess the associations between different glucose-lowering agents and CIAKI as well as adverse cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of CIAKI was 11.7% (244\/2082). Patients with CIAKI had significantly worse short-term in-hospital outcomes. In multivariable logistic regression analysis, SGLT2i use (OR = 1.892,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.040), total cholesterol (OR = 1.494,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), elevated blood urea nitrogen (OR = 1.082,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.022), and diuretic use (OR = 3.389,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) were associated with an increased risk of CIAKI. After propensity score matching, SGLT2i use remained associated with a higher incidence of CIAKI (OR = 2.384,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003), DPP4 inhibitor use was associated with a lower observed incidence of CIAKI (OR = 0.179,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.027). In contrast, no statistically significant associations were observed for other glucose-lowering agents with respect to CIAKI or overall adverse cardiovascular outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2i use may be associated with a higher incidence of CIAKI in patients with T2DM undergoing CAG or PCI. These findings may aid risk stratification and clinical management. Further research is needed to clarify the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261456870","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:49:56Z","timestamp":1780044596000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoglycemic agents and contrast-induced acute kidney injury in type 2 diabetes: A retrospective cohort study of patients undergoing coronary angiography or percutaneous coronary intervention"],"prefix":"10.1177","volume":"109","author":[{"given":"Danning","family":"Guo","sequence":"first","affiliation":[{"name":"Nanjing First Hospital"},{"name":"Nanjing Medical University"},{"name":"Xuzhou First People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9090-6264","authenticated-orcid":false,"given":"Xia","family":"Du","sequence":"additional","affiliation":[{"name":"Sir Run Run Hospital"},{"name":"Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3262-3590","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital"},{"name":"Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Liu","sequence":"additional","affiliation":[{"name":"Sir Run Run Hospital"},{"name":"Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-6684","authenticated-orcid":false,"given":"Mengqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital"},{"name":"Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.196578"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S534736"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.989243"},{"key":"e_1_3_8_5_2","first-page":"20260203","article-title":"Contrast-induced acute kidney injury: from pathophysiology to risk prediction and prevention strategies","author":"Anjanappa P","year":"2026","unstructured":"Anjanappa P, Kularia S, Shrestha Y. Contrast-induced acute kidney injury: from pathophysiology to risk prediction and prevention strategies. J Basic Clin Physiol Pharmacol 2026: 20260203. https:\/\/doi.org\/10.1515\/jbcpp-2025-0222","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12080620"},{"key":"e_1_3_8_7_2","first-page":"20250910","article-title":"PUM2 Lowers HDAC9 mRNA Stability to Improve Contrast-Induced Acute Kidney Injury through Attenuating Oxidative Stress and Promoting Autophagy","author":"Chen W","year":"2025","unstructured":"Chen W, Lu H, Dai W, et al. PUM2 Lowers HDAC9 mRNA Stability to Improve Contrast-Induced Acute Kidney Injury through Attenuating Oxidative Stress and Promoting Autophagy. Diabetes Metab J 2025: 20250910. https:\/\/doi.org\/10.4093\/dmj.2024.0396","journal-title":"Diabetes Metab J"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.117838"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5247-4"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04387-x"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000527384"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1307715"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-025-01170-4"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.01.015"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-02148-2"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad254"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01476-x"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101315"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2225-0"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03570-6"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab332"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S002"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74233-7"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1744473"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-021-00609-7"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-017-0602-6"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-024-00684-y"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S300494"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.918167"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0588"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-021-01442-z"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S011"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080257"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2022.1759"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08395-7"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020246"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082167"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-27330-0"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261456870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504261456870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261456870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:42:09Z","timestamp":1782848529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504261456870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/00368504261456870"],"URL":"https:\/\/doi.org\/10.1177\/00368504261456870","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"00368504261456870"}}