{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:59:01Z","timestamp":1790747941252,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Institutional Program","award":["E015, ISSSTE"],"award-info":[{"award-number":["E015, ISSSTE"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Visceral adipose tissue (VAT) produces several adipokines; however, VAT adipocytes\u2019 gene expression has not been related with cardio-metabolic components. The present study aimed to explore associations between gene expression in human primary VAT adipocytes\u2019 and cardio-metabolic components in subjects who live with Metabolically Unhealthy Obesity (MUO) compared with subjects who live with Metabolically Healthy Obesity (MHO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study of patients who live with obesity, who underwent bariatric\/metabolic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-five patients (18 MHO and 27 MUO) aged 44 years, main co-morbidities Diabetes and Hypertension, were analyzed. MUO showed younger age and higher cardio-metabolic risk, as well as larger adipocyte\u00b4s sizes. Primary cultured adipocytes were isolated from trans-surgical VAT sample, then cDNA was analyzed for the expression of 92 genes, further distributed as MUO\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      MHO and clustered according to their linkage with cardio-metabolic components. Higher expression of genes like EDN1, IL-6, ADIPOQ, GSTA2, TGF\u03b2, WNT3A, KDR, MAPK3, vWF (p&lt;0.04); as well as reduced NOS2, PDGFA, HAMP and RARRES2 (p&lt;0.01) were observed across clusters of hyperglycemia, hypertension, dyslipidaemia, and central obesity, broadly implicating pathways related to inflammation, oxidative stress, endothelial dysfunction, insulin resistance, and vascular regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings from the present exploratory analysis show that cardio-metabolic risk is associated to VAT adipocytes\u2019 gene expression; particularly those genes related to oxidative stress, insulin resistance, inflammation, endothelial dysfunction, athero-thrombosis, and lower vasodilation. Further longitudinal and mechanistic studies are required to clarify the directionality and clinical significance of these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261465537","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:01:55Z","timestamp":1783166515000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gene expression in visceral adipocytes in metabolically healthy and unhealthy obesity: A cross-sectional analysis of associations with cardiometabolic components"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-5658","authenticated-orcid":false,"given":"Juan Antonio","family":"Su\u00e1rez-Cuenca","sequence":"first","affiliation":[{"name":"Departamento de Investigaci\u00f3n Cl\u00ednica, Centro M\u00e9dico Nacional \u201c20 de Noviembre\u201d, ISSSTE, Mexico City, 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