{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:20:42Z","timestamp":1783012842619,"version":"3.54.6"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Xuzhou Municipal Health Commission Medical Science and Technology Innovation Project","award":["(XWKYHT20250086)"],"award-info":[{"award-number":["(XWKYHT20250086)"]}]},{"name":"The Medical research project of Jiangsu Provincial Health Commission","award":["(M2024032)"],"award-info":[{"award-number":["(M2024032)"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["(82302798)"],"award-info":[{"award-number":["(82302798)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the predictive value of the combined triglyceride-glucose index (TyG) and glycemic variability (GV) for all-cause mortality in critically ill patients with sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used MIMIC-IV v3.1 as the development cohort and the temporally independent MIMIC-III CareVue subset as the validation cohort. Patients were divided into six groups based on the median TyG index (9.34) and GV tertiles (\u226420.54, 20.54\u201328.11, and &gt;28.11). The primary outcome was 90-day all-cause mortality. Analyses were performed using Kaplan\u2013Meier survival curves, Cox proportional hazards models, and restricted cubic splines, supplemented with subgroup analyses and external validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 1792 patients from MIMIC-IV and 947 patients from the MIMIC-III CareVue subset. In the fully adjusted Cox proportional hazards model, the G6 group (TyG &gt; 9.34 and GV &gt; 28.11) exhibited the highest 90-day all-cause mortality risk compared with the G1 group (TyG \u2264 9.34 and GV \u2264 20.54) (HR = 2.366, 95% CI: 1.595\u20133.509). The absolute 90-day mortality rate increased from 10.3% in G1 to 27.2% in G6. Kaplan\u2013Meier analysis revealed significant differences in cumulative mortality across the TyG\u2013GV risk groups during the 90-day follow-up (log-rank P &lt; 0.001), with the lowest survival rate observed in G6. The combined TyG and GV model showed a modest but statistically significant improvement in discrimination compared with the baseline model for 90-day mortality, with the AUC increasing from 0.730 (95% CI, 0.700\u20130.760) to 0.743 (95% CI, 0.714\u20130.773) (\u0394AUC = 0.013, P = 0.048). The continuous net reclassification improvement (cfNRI) and integrated discrimination improvement (IDI) further supported the incremental value of TyG and GV added to the baseline model. Subgroup analyses showed generally consistent directions of association without significant interactions, and external validation supported the robustness of these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combined phenotype of elevated TyG index (&gt;9.34) and elevated GV (&gt;28.11) was associated with increased short- and long-term all-cause mortality risks and provided supplementary prognostic information in critically ill patients with sepsis; prospective validation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261465749","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:41:42Z","timestamp":1782848502000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of the triglyceride-glucose index combined with glycemic variability for all-cause mortality in patients with sepsis: A retrospective cohort study"],"prefix":"10.1177","volume":"109","author":[{"given":"Ao","family":"Wang","sequence":"first","affiliation":[{"name":"The Affiliated Huaihai Hospital of Xuzhou Medical University"},{"name":"The 71st Group Army Hospital of PLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Fu","sequence":"additional","affiliation":[{"name":"The Affiliated Huaihai Hospital of Xuzhou Medical University"},{"name":"The 71st Group Army Hospital of PLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Huaihai Hospital of Xuzhou Medical University"},{"name":"The 71st Group Army Hospital of PLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Huaihai Hospital of 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