{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:10:59Z","timestamp":1793329859447,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Guizhou Tabacco Company Qianxinan Branch","award":["Zhong Yan Qian Ke [2023] No 6"],"award-info":[{"award-number":["Zhong Yan Qian Ke [2023] No 6"]}]},{"name":"Guizhou Guiwang Biotechnology Limited Company","award":["Zun Shi Ke He CXZX [2025] No 3"],"award-info":[{"award-number":["Zun Shi Ke He CXZX [2025] No 3"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      A large number of substrates after harvesting the fruiting bodies of\n                      <jats:italic toggle=\"yes\">Cordyceps militaris<\/jats:italic>\n                      have been discarded or only used as feed and fertilizer. In this study, we aimed to investigate the potential utilization value of residual substrates under industrial cultivation of\n                      <jats:italic toggle=\"yes\">C. militaris<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The various bioactive substances in\n                      <jats:italic toggle=\"yes\">C. militaris<\/jats:italic>\n                      fruiting body and substrate were measured and compared by colorimetry, HPLC, burning method, Kjeldahl legal nitrogen method, and GC-MS et al. The fruiting body was taken as a reference to better reflect the internal quality of substrate. Finally, a response surface experiment was conducted to investigate the effects of drying temperature, humidity, and time on the retention rate of\n                      <jats:italic toggle=\"yes\">C. militaris<\/jats:italic>\n                      polysaccharide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the substrate, the content of polysaccharide was 4.68%, the cordycepic acid content was 7.95%, which were significantly higher than the content in the fruiting body. The content of cordycepin was as high as 1.13%, which was more than 4 times of the fruiting body. The crude fat content was also higher than that in fruiting body. In addition, 17 amino acids were detected in the substrate, including 7 essential amino acids. Moreover, several volatile components with drug properties were detected in the substrate. Finally, the optimum drying parameters of the substrates are as follows: drying temperature, 59\u00b0C; humidity, 16%; time, 24 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlighted the available value of substrate is no less than the fruiting body, which is an ideal food supplement and pharmaceutical agent, which can be served as a good source of healthy substances potentially bioavailable for humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261467525","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:42:05Z","timestamp":1784022125000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploration of the potential utilization value in\n                    <i>Cordyceps militaris<\/i>\n                    substrate after industrial cultivation in terms of nutritional and pharmaceutical applications"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0998-4978","authenticated-orcid":false,"given":"YouCui","family":"Yang","sequence":"first","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qiao","sequence":"additional","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YeMing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaoJiao","family":"Qu","sequence":"additional","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dai","sequence":"additional","affiliation":[{"name":"Guizhou Tabacco Company Qianxinan Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Gao","sequence":"additional","affiliation":[{"name":"Guizhou Tabacco Company Qianxinan Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaLi","family":"Guo","sequence":"additional","affiliation":[{"name":"Guizhou Tabacco Company Qianxinan Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zou","sequence":"additional","affiliation":[{"name":"Guizhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.10.021"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-022-00551-z"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10020405"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2019.03.003"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods8110590"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.575704"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1904.04004"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122735"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196576"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.2019031138"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109241"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.2019033257"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7050342"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1386-y"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.06.009"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.8097"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-009-0024-0"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-015-7235-4"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods11233933"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym10040430"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.973677"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4279"},{"key":"e_1_3_7_24_2","first-page":"1","article-title":"Optimizing cultivation of Cordyceps militaris for fast growth and cordycepin overproduction using rational design of synthetic media","volume":"18","author":"Raethong N","year":"2019","unstructured":"Raethong N, Wang H, Nielsen J, et al. 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