{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:59:14Z","timestamp":1790747954527,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This prospective study evaluated the therapeutic efficacy of Diosgenin in mitigating Oxazolone-induced ulcerative colitis in male BALB\/c mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Mice aged 10\u201311 weeks were randomized into five groups and subjected to a nine-day protocol involving skin sensitization and intra-rectal Oxazolone challenge. Diosgenin was administered orally at 3 mg\/kg and 30 mg\/kg twice daily, with Tofacitinib at 60 mg\/kg as a reference control. Disease severity was assessed via clinical activity scores, which include tested parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oxazolone-induced acute colitis was characterized by significant weight loss, increased diarrhoea scores, and an &gt;8-fold increase in rectal bleeding scores compared with vehicle-treated mice, confirming successful disease induction (p &lt; 0.05). Diosgenin-treated mice showed significant recovery. Disease Activity Index (DAI) scores improved by 40% in the 3 mg\/kg Diosgenin group, 45% in the 30 mg\/kg Diosgenin group, and 67% in the Tofacitinib-treated group by Day 2. Stool consistency improved by 52%, 33%, and 49% on Day 1, and by 33%, 61%, and 64% on Day 2 in the 3 mg\/kg and 30 mg\/kg Diosgenin groups, and the 60 mg\/kg Tofacitinib groups respectively. Molecular analysis revealed a dose-dependent suppression of Th2 cytokines: IL-4 levels were reduced by 71%, 90%, and 86%, and IL-13 levels by 75%, 79%, and 90% in the Diosgenin 3mg\/kg and 30 mg\/kg groups, and Tofacitinib 60 mg\/kg group respectively. Diosgenin markedly suppressed colonic pSTAT3 expression, with reductions of 92% and 99%, in the Diosgenin 3mg\/kg and 30 mg\/kg groups and &gt;90% in the Tofacitinib 60 mg\/kg group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest Diosgenin offers substantial protection against Oxazolone-induced colitis via cytokine modulation and pSTAT3 inhibition, highlighting its potential as a natural anti-inflammatory agent for colitis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261470488","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:43:07Z","timestamp":1784634187000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study"],"prefix":"10.1177","volume":"109","author":[{"given":"Ashwini","family":"Narayan","sequence":"first","affiliation":[{"name":"Sri Jayachandra College in Engineering, JSS Science and Technology University, JSS Technical Institutions Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Babu Shubha","sequence":"additional","affiliation":[{"name":"University of Mysore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Baker","sequence":"additional","affiliation":[{"name":"Karnataka State Open University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan Raj","family":"Sathyanarayana","sequence":"additional","affiliation":[{"name":"Karnataka State Open University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiyaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Qassim University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-9428","authenticated-orcid":false,"given":"Nanjunda Swamy","family":"Shivananju","sequence":"additional","affiliation":[{"name":"Sri Jayachandra College in Engineering, JSS Science and Technology University, JSS Technical Institutions Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_3_5_2_2","first-page":"e41120","article-title":"Advancements in inflammatory bowel disease: A narrative review of diagnostics, management, epidemiology, prevalence, patient outcomes, quality of life, and clinical presentation","volume":"15","author":"Muzammil MA","year":"2023","unstructured":"Muzammil MA, Fariha F, Patel T, et al. 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