{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:57:46Z","timestamp":1790747866456,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) integrates inflammatory burden with anti-inflammatory lipid status, yet its prognostic value for long-term outcomes in critically ill patients with coronary heart disease (CHD) remains unclear. This study aimed to evaluate the association between MHR and 1-year all-cause mortality in this high-risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study using data from the Medical Information Mart for Intensive Care (MIMIC)-III and IV databases (2001\u20132019). Adult patients (\u226518 years) with CHD were included, excluding those with ICU stay &lt;24 hours or missing monocyte count\/HDL-C data, yielding 3,004 patients. MHR was calculated as monocyte count (\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L) divided by HDL-C (mmol\/L). The primary outcome was 1-year all-cause mortality. Kaplan-Meier analysis and log-rank tests compared survival across MHR tertiles. Restricted cubic splines assessed dose-response relationships. Multivariable Cox proportional hazards regression with progressive adjustment evaluated MHR-mortality associations. Subgroup analyses examined effect modification across predefined clinical characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort had a mean age of 73.5 years, with 65.8% males. Patients in the highest MHR tertile (T3) demonstrated greater disease severity, higher comorbidity burden, and more intensive treatment requirements. Kaplan-Meier analysis revealed significantly lower 1-year survival in T3 versus T1 (68% vs. 80%, log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Restricted cubic spline analysis showed a linear relationship (P for non-linearity=0.441). After adjustment for demographics, vital signs, comorbidities, laboratory parameters, and treatments, each 1-unit increase in MHR conferred a HR of 1.33 (95% CI: 1.18-1.51), per-SD HR = 1.10, 95% CI: 1.03-1.17. Tertile analysis demonstrated a dose-response pattern, with T3 showing HR=1.25 (95% CI: 1.04-1.51) compared with T1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for trend&lt;0.05). Subgroup analyses revealed consistent associations across most strata.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated MHR is associated with increased 1-year mortality in critically ill CHD patients. As a readily available composite marker, MHR may have supplementary prognostic relevance, but its clinical utility requires prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261473732","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:11:32Z","timestamp":1785355892000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Monocyte-to-HDL-cholesterol ratio and 1-year mortality in critically ill coronary heart disease: A MIMIC cohort study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-3405","authenticated-orcid":false,"given":"Ding","family":"Li","sequence":"first","affiliation":[{"name":"Anesthesia &amp; Operation Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Key Laboratory of Precision Translational Medicine in Anesthesiology and Pain, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3727-2333","authenticated-orcid":false,"given":"Zhiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anesthesia &amp; Operation Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Key Laboratory of Precision Translational Medicine in Anesthesiology and Pain, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000757"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.049"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030798"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_7_8_2","first-page":"2525","article-title":"Inflammation during the life cycle of the atherosclerotic plaque","volume":"117","author":"Libby P","year":"2021","unstructured":"Libby P. 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