{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:12Z","timestamp":1792787652853,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Liangxi District Association for Science and Technology \u201cLiangxi Science Star \u2022 Youth Set Sail\u201d Talent Nurturing Program"},{"name":"Youth Project of Wuxi Municipal Health Commission","award":["Q202528"],"award-info":[{"award-number":["Q202528"]}]},{"name":"The Soft Science Research Project of Wuxi Science and Technology Association","award":["KX-25-B09"],"award-info":[{"award-number":["KX-25-B09"]}],"id":[{"id":"https:\/\/ror.org\/03ab2g513","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wuxi Medical Development Discipline-Obstetrics and Gynecology","award":["FZXK2021008"],"award-info":[{"award-number":["FZXK2021008"]}]},{"name":"The Postdoctoral Fund of the Affiliated Women\u2019s Hospital of Jiangnan University"},{"name":"Wuxi City \u201cTaihu Light\u201d Science and Technology Key Project","award":["Healthcare Technology Research Y20242116"],"award-info":[{"award-number":["Healthcare Technology Research Y20242116"]}]},{"name":"Medical Key Strategic Project of Wuxi Health Commission"},{"name":"Wuxi Maternal and Child Health Sciences Research Project","award":["FYKY202203"],"award-info":[{"award-number":["FYKY202203"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to validate the prognostic discriminatory power of the revised International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system and to evaluate the association between regional lymph node resection (RLNR) and survival in cervical cancer (CC) patients who underwent RLNR followed by chemotherapy and radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study utilizing the Surveillance, Epidemiology, and End Results (SEER) database (2000\u20132018), patients were categorized into early-stage (IA\/IB1-IB2\/IIA1) and locally advanced-stage (IB3\/IIA2-IIB\/III\/IVA) groups. Survival outcomes were analyzed using Kaplan\u2013Meier, univariate and multivariate Cox regression (including time-dependent), and year-of-diagnosis stratified analyses, applied to crude, inverse probability of treatment weighting (IPTW)-weighted, and propensity score matching (PSM)-matched models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The FIGO 2018 system revealed significant survival differences between IB1 vs IB2 and IIIC1 vs IIIA\/IIIB (all p &lt; 0.001). In early-stage patients, RLNR conferred no significant survival benefit. However, in locally advanced-stage patients, RLNR with primary surgery was associated with better survival than RLNR alone. In the cohort without primary surgery, RLNR alone was consistently identified as a prognostic factor versus non-surgery across all three analytical models (IPTW as primary, PSM as sensitivity; all p&lt;0.001). The hazard ratios for RLNR alone versus non-surgery were all below 1.000, and year-of-diagnosis stratified analyses further supported this protective association, with consistently directional estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggested the prognostic value of the FIGO 2018 staging system and hypothesized that RLNR is a prognostic factor for better survival compared with chemotherapy and radiotherapy alone in locally advanced-stage CC, although the limitations of a retrospective study must be acknowledged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261481941","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:12:57Z","timestamp":1788891177000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of regional lymph node resection with survival in patients with locally advanced-stage cervical cancer: A retrospective SEER-based cohort study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6962-6138","authenticated-orcid":false,"given":"Aiyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Wuxi Maternity and Child Health Care Hospital"},{"name":"Affiliated Women\u2019s Hospital of Jiangnan University"},{"name":"Jiangnan University"},{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remila","family":"Rezhake","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyin","family":"Huang","sequence":"additional","affiliation":[{"name":"Bortala Mongolian Autonomous Prefecture People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzhalinuer","family":"Abulizi","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wuxi Maternity and Child Health Care Hospital"},{"name":"Affiliated Women\u2019s Hospital of Jiangnan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70277"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010331"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.02.009"},{"key":"e_1_3_7_5_2","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): Cervical Cancer. Version 2.2026. Plymouth Meeting (PA): National Comprehensive Cancer Network 2025 Available from. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cervical.pdf"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2020.31.e79"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.07.007"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000000"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2021.32.e4"},{"issue":"06","key":"e_1_3_7_10_2","first-page":"474","article-title":"Guidelines for Diagnosis and Treatment of Cervical Cancer (2021 Edition)","volume":"31","author":"Chinese Anti-Cancer Association, Committee of Gynecologic Oncology","year":"2021","unstructured":"Chinese Anti-Cancer Association, Committee of Gynecologic Oncology. Guidelines for Diagnosis and Treatment of Cervical Cancer (2021 Edition). China Oncology 2021; 31(06): 474\u2013489. https:\/\/doi.org\/10.19401\/j.cnki.1007-3639.2021.06.06","journal-title":"China Oncology"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.02.12"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004429"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4368"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30753-1"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-026-02222-7"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2026.02.012"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.08.003"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2241::AID-CNCR20>3.0.CO;2-T"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081974"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.04.006"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1561836"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2023.12.010"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.22514\/ejgo.2025.051"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-11732-1"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86283-2"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.10.026"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-025-02697-2"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.108522"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00977-w"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12629"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-2025-1-2924"},{"key":"e_1_3_7_33_2","doi-asserted-by":"crossref","first-page":"e081905","DOI":"10.1136\/bmj-2024-081905","article-title":"Core GRADE 3: rating certainty of evidence-assessing inconsistency","volume":"389","author":"Guyatt G","year":"2025","unstructured":"Guyatt G, Schandelmaier S, Brignardello-Petersen R, et al. Core GRADE 3: rating certainty of evidence-assessing inconsistency. BMJ 2025; 389: e081905. https:\/\/doi.org\/10.1136\/bmj-2024-081905","journal-title":"BMJ"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17213487"},{"issue":"11","key":"e_1_3_7_35_2","first-page":"e70021","article-title":"Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review","volume":"7","author":"Zhang X","year":"2024","unstructured":"Zhang X, Yu H, Chen K, et al. Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review. Cancer Rep (Hoboken) 2024; 7(11): e70021. https:\/\/doi.org\/10.1002\/cnr2.70021","journal-title":"Cancer Rep (Hoboken)"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2023.02.001"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16040717"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108484"},{"issue":"7","key":"e_1_3_7_39_2","first-page":"602","article-title":"[Expression of PD-L1 and tumor infiltrating lymphocyte markers in uterine cervical carcinoma]","volume":"51","author":"Ma ZY","year":"2022","unstructured":"Ma ZY, Zhu YF, Liu ZH, et al. [Expression of PD-L1 and tumor infiltrating lymphocyte markers in uterine cervical carcinoma]. Zhonghua Bing Li Xue Za Zhi 2022; 51(7): 602\u2013607. https:\/\/doi.org\/10.3760\/cma.j.cn112151-20220403-00252, Chinese.","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55200-2"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15110523"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001973"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01808-7"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-004223"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2023.34.e55"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2024.35.e57"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261481941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504261481941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261481941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:18:27Z","timestamp":1790745507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504261481941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/00368504261481941"],"URL":"https:\/\/doi.org\/10.1177\/00368504261481941","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"00368504261481941"}}