{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:40:33Z","timestamp":1793824833927,"version":"4.6.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The lactate-to-hemoglobin ratio (LHBR) integrates information on metabolic stress and oxygen-carrying capacity. This study aimed to evaluate the association between admission LHBR and mortality among critically ill patients with type 1 acute myocardial infarction (AMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the MIMIC-IV database (version 3.1) and included adult patients admitted to the intensive care unit (ICU) with type 1 AMI. LHBR was calculated from the first lactate and hemoglobin levels around ICU admission. The primary outcome was 30-day mortality; secondary outcomes were 60-, 90-, and 180-day mortality. Associations were evaluated using restricted cubic spline analyses, Cox proportional hazards regression models, and receiver operating characteristic (ROC) curve analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4,651 patients were included and categorized into LHBR tertiles using cutoffs of \u22640.127 (T1), &gt;0.127\u20130.209 (T2), and &gt;0.209 (T3). Restricted cubic spline analyses showed significant nonlinear associations between LHBR (as well as the natural logarithm-transformed LHBR) and all mortality outcomes (all P-nonlinear &lt;0.05). In the adjusted purposeful selection model, both intermediate (T2) and high (T3) LHBR tertiles were associated with increased 30-day mortality compared with the lowest tertile (T1) (T2 vs T1: HR 1.32, 95% CI 1.07\u20131.64; T3 vs T1: HR 2.05, 95% CI 1.66\u20132.52). Comparable findings were observed for 60-day mortality (HRs 1.29 and 1.94), 90-day mortality (HRs 1.30 and 1.89), and 180-day mortality (HRs 1.26 and 1.75), respectively. Admission LHBR demonstrated slightly better discrimination for 30-day mortality than either lactate or hemoglobin alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher admission LHBR was associated with increased short-term and long-term mortality in critically ill patients with type 1 AMI. Further studies are warranted to validate these findings and determine the clinical utility of LHBR in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261484878","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:20:07Z","timestamp":1787872807000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Admission lactate-to-hemoglobin ratio and mortality in critically ill patients with type 1 acute myocardial infarction: A mimic-iv database study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0117-9482","authenticated-orcid":false,"given":"Thanh Luan","family":"Nguyen","sequence":"first","affiliation":[{"name":"Nam Can Tho University"},{"name":"Nam Can Tho University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Bao Yen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Oanh","family":"Hoang","sequence":"additional","affiliation":[{"name":"Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Nhu Y","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Thanh","family":"Le","sequence":"additional","affiliation":[{"name":"Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong Dang","family":"Tran","sequence":"additional","affiliation":[{"name":"Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_3_7_3_2","first-page":"e41","article-title":"2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"151","author":"Martin SS","year":"2025","unstructured":"Martin SS, Aday AW, Allen NB, et al. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. 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