{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:50:31Z","timestamp":1792108231387,"version":"4.4.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006014","name":"College of Medicine and Health Sciences, United Arab Emirates University","doi-asserted-by":"publisher","award":["G00005308 and G00004202"],"award-info":[{"award-number":["G00005308 and G00004202"]}],"id":[{"id":"10.13039\/501100006014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n Objectives<\/jats:title>\n \n Carbapenem-resistant\n Enterobacterales<\/jats:italic>\n have emerged as a major global health concern owing to their rapid dissemination and limited therapeutic options. Here we report the first detection of\n bla<\/jats:italic>\n \n OXA-244<\/jats:italic>\n <\/jats:sub>\n in\n Escherichia coli<\/jats:italic>\n from the United Arab Emirates (UAE) and characterize two isolates genotypically and phenotypically, comparing them with geographically diverse public strains sharing the same sequence type (ST).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The isolates were recovered from the urine of a patient with metastatic cancer and from the abdominal fluid of a patient with sepsis. Antimicrobial susceptibility testing, including newer \u03b2-lactam and \u03b2-lactam\/\u03b2-lactamase-inhibitors (BL\/BLIs), and whole-genome sequencing were performed. Comparative genomic analysis was conducted against global and a defined Middle Eastern\/North African subset matched by ST and carbapenemase profile.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The two isolates were genetically distinct: one carried\n bla<\/jats:italic>\n \n OXA-244<\/jats:italic>\n <\/jats:sub>\n alone and belonged to ST131, whereas the other harboured dual carbapenemases (\n bla<\/jats:italic>\n \n OXA-244<\/jats:italic>\n <\/jats:sub>\n and\n bla<\/jats:italic>\n \n NDM-5<\/jats:italic>\n <\/jats:sub>\n ) and belonged to ST361. Chromosomal location of\n bla<\/jats:italic>\n \n OXA-244<\/jats:italic>\n <\/jats:sub>\n was confirmed by Southern hybridization. Both isolates were multidrug-resistant, enriched with resistance genes spanning multiple antibiotic classes and virulence genes that support their pathogenicity. Phenotypically, the ST131 isolate remained susceptible to ceftazidime\/avibactam and several BL\/BLIs combinations, whereas the NDM-5-carrying ST361 isolate was resistant to ceftazidime\/avibactam, cefepime\/enmetazobactam, and cefepime\/taniborbactam, highlighting the therapeutic challenge posed by metallo-\u03b2-lactamase co-production. Notably, both isolates remained susceptible to cefepime\/zidebactam, cefiderocol, tigecycline, and colistin, and both showed low MICs for meropenem\/xeruborbactam. The phylogenetic placement of both UAE isolates is consistent with membership in distinct carbapenem-resistant lineages detected across multiple countries; however, the routes of acquisition could not be inferred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the first report of\n bla<\/jats:italic>\n \n OXA-244<\/jats:italic>\n <\/jats:sub>\n in\n E. coli<\/jats:italic>\n from the UAE with two unrelated high-risk backgrounds. A dual OXA-244\/NDM-5 ST361 lineage disseminated regionally since 2019 was identified. Because OXA-244 evades routine detection, genomic surveillance is needed to detect such emerging variants and to inform appropriate antimicrobial therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00368504261493836","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:11:18Z","timestamp":1791933078000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of\n bla<\/i>\n \n OXA-244<\/i>\n <\/sub>\n in a single and dual-carbapenemase-producing clinical isolates of\n Escherichia coli<\/i>\n from the United Arab Emirates"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-6264","authenticated-orcid":false,"given":"Farah","family":"Al-Marzooq","sequence":"first","affiliation":[{"name":"United Arab Emirates University"},{"name":"United Arab Emirates University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha","family":"Chandran","sequence":"additional","affiliation":[{"name":"United Arab Emirates University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akela","family":"Ghazawi","sequence":"additional","affiliation":[{"name":"United Arab Emirates University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushal","family":"Allam","sequence":"additional","affiliation":[{"name":"United Arab Emirates University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Collyns","sequence":"additional","affiliation":[{"name":"Tawam Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1690417"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14030221"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.08.004"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1796557"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04296-1"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics15020176"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1247627"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.microb.2026.100700"},{"key":"e_1_3_8_10_2","volume-title":"StatPearls. 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