{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:00Z","timestamp":1792787700189,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical Scientific Research Projects of Wuhan Municipal Health Commission","award":["WX23Z02"],"award-info":[{"award-number":["WX23Z02"]}],"id":[{"id":"https:\/\/ror.org\/04jjn5s14","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the impact of routine- and high-dose ulinastatin on the occurrence of burn sepsis, early-phase inflammatory responses and organ function indices in patients with extremely severe burns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted involving 106 patients with extremely severe burns. These patients were categorized into three groups: routine treatment, routine-dose ulinastatin treatment, and high-dose ulinastatin treatment. All patients received standard care, including fluid resuscitation, anti-infection therapy, and surgical debridement. Patients in the two ulinastatin groups received intravenous ulinastatin at doses of 100 kU and 300 kU three times daily for seven days. Inflammatory and organ function markers were measured at admission and on post-burn days 3 and 7. The primary clinical outcome within 30 days after burn injury was burn sepsis. Multivariable binary logistic regression was performed to identify predictors associated with burn sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On post-burn day 7, the high-dose ulinastatin treatment group exhibited lower white blood cell (WBC) and neutrophil counts, and blood urea nitrogen (BUN) than the routine treatment group (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). In addition, the routine-dose treatment group showed a reduced neutrophil count compared to the routine treatment group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The 30-day incidence of burn sepsis was significantly lower in the high-dose ulinastatin treatment group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Multivariable binary logistic regression analysis identified that high-dose ulinastatin therapy was independently associated with a lower risk of burn sepsis, whereas inhalation injury and time to first surgical debridement were independently associated with a higher risk of burn sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that high-dose ulinastatin is associated with a blunted inflammatory response, lower BUN levels, and lower odds of burn sepsis in patients with extremely severe burns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261498136","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:41:22Z","timestamp":1792060882000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of different doses of ulinastatin on early inflammatory responses and prognosis in patients with extremely severe burns: A retrospective observational cohort study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5656-445X","authenticated-orcid":false,"given":"Nanhong","family":"Jiang","sequence":"first","affiliation":[{"name":"Wuhan Third Hospital (Tongren Hospital of Wuhan University)"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Third Hospital (Tongren Hospital of Wuhan University)"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuhan Third Hospital (Tongren Hospital of Wuhan University)"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Lu","sequence":"additional","affiliation":[{"name":"Wuhan Third Hospital (Tongren Hospital of Wuhan University)"},{"name":"Hubei Provincial Clinical Medical Research Center for Burns"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.04.009"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193073"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1804600310"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom16060806"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.04.19"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108908"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041145"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000546"},{"key":"e_1_3_5_11_2","first-page":"3207","article-title":"Expert consensus on the application of ulinastatin in common clinical critical illness","volume":"26","author":"Expert Consensus Group","year":"2023","unstructured":"Expert Consensus Group. Expert consensus on the application of ulinastatin in common clinical critical illness. (in Chinese). Chin Gen Pract 2023; 26: 3207\u20133219. https:\/\/doi.org\/10.12114\/j.issn.1007-9572.2023.0157","journal-title":"Chin Gen Pract"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1267"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1413986"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8984696"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.05.013"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.08.024"},{"key":"e_1_3_5_18_2","first-page":"224","article-title":"Effects of different doses of ulinastatin on systemic inflammatory response syndrome and hepatorenal function in patients with severe burns","volume":"33","author":"Shi LJ","year":"2017","unstructured":"Shi LJ, Chang PF, Liu JG, et al. Effects of different doses of ulinastatin on systemic inflammatory response syndrome and hepatorenal function in patients with severe burns. (in Chinese). 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Effects of ulinastatin on immune function of patients with severe burn injury. 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Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-dose study. 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