{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:02:17Z","timestamp":1777899737730,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:p>\n                    The cardio-pulmonary and biochemical changes observed in a case of McArdle's disease, exercising with increasing work rates to exhaustion in \u00b0the \u201csecond-wind\u201d phase of exercise are reported for the first time. A \u00b0work rate of 2 75\u2013325 \u00b0watts was achieved. Venous blood lactate remained unchanged throughout. The plasma ammonium level reached a plateau of approximately 400 \u00b0mmol\/l at 100 \u00b0watts. At a work rate of 150\u2013175 watts the ratio of O\n                    <jats:sub>2<\/jats:sub>\n                    consumption to CO\n                    <jats:sub>2<\/jats:sub>\n                    production increased, the inverse of an anaerobic threshold. Maximal cardio-pulmonary responses were achieved at 200 watts. During the final periods of exercise from 200 to 275\/325 \u00b0watts pulmonary ventilation did not significantly change but there was a decrease in the venous blood H\n                    <jats:sup>+<\/jats:sup>\n                    concentration, and pO\n                    <jats:sub>2<\/jats:sub>\n                    and in increase in the pCO\n                    <jats:sub>2<\/jats:sub>\n                    Creatine supplementation at 25 \u00b0g\/day for five days did not improve exercise performance.\n                  <\/jats:p>","DOI":"10.1177\/003693300304800206","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T21:34:52Z","timestamp":1484084092000},"page":"46-48","source":"Crossref","is-referenced-by-count":8,"title":["Exercise to Exhaustion in the Second-Wind Phase of Exercise In A Case of McArdle's Disease with and without Creatine Supplementation"],"prefix":"10.1177","volume":"48","author":[{"given":"D St J O","family":"Reilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Royal Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hinnie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Alexandra Hospital, Paisley"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"J\u00b0Galloway","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Royal Hospital for Sick Children, Yorkhill, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"bibr1-003693300304800206","first-page":"935","volume-title":"The Metabolic Bases of Inherited Disease","volume":"1","author":"Chen YT","year":"1995","edition":"7"},{"key":"bibr2-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(61)90075-4"},{"key":"bibr3-003693300304800206","first-page":"403","volume":"35","author":"Yamauchi A","year":"1996","journal-title":"Int\u00b0Med"},{"key":"bibr4-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1999.tb01777.x"},{"key":"bibr5-003693300304800206","first-page":"126","volume-title":"The Oxford Textbook of Sports Medicine","author":"Williams MH.","year":"1998","edition":"2"},{"key":"bibr6-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880687"},{"key":"bibr7-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"bibr8-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"bibr9-003693300304800206","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.2.E167"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693300304800206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693300304800206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:13:16Z","timestamp":1777630396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/003693300304800206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["10.1177\/003693300304800206"],"URL":"https:\/\/doi.org\/10.1177\/003693300304800206","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}