{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:03:51Z","timestamp":1777899831793,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>Although the management of thymomas has been extensively evaluated, the value of prognostic factors in the outcome of these patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results:<\/jats:title>\n                    <jats:p>The medical records of all patients who underwent resection of thymoma between January 1985 and September 2010 at a single thoracic unit were reviewed. Patients were followed up with reference to disease recurrence and development of additional malignancies (AM). Total thymectomy was performed in all 68 cases. Mean follow-up time was four years. Mean survival was 63.9 months. Mean disease-free interval was 13 months. Factors affecting prognosis were Masaoka staging and WHO histological sub-type. Patients with thymomas had a higher risk of developing AM when compared with a control population of individuals with other tumours ( p\u2009=\u20090.0002). Among thymomas, the cortical subtype was associated with a higher risk of AM ( p\u2009=\u20090.047) and mortality ( p\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This data confirms that Masaoka staging and WHO histologic sub-type are the most important prognostic factors in patients with thymoma. Moreover, thymomas predominantly arising from the thymic cortex are associated with a higher risk of developing other malignancies and with poorer survival. The cortical origin of thymoma could therefore be considered as a significant prognostic factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0036933013518147","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T22:38:20Z","timestamp":1390603100000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome in excised thymomas: role of prognostic factors and impact of additional malignancies on survival"],"prefix":"10.1177","volume":"59","author":[{"given":"F","family":"Granato","sequence":"first","affiliation":[{"name":"Professor of Genetics, Department of Cardio-Thoracic Surgery, Golden Jubilee National Hospital, Scotland"},{"name":"Professor of Genetics, Doctorate School of Oncology and Genetic, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Blackhall","sequence":"additional","affiliation":[{"name":"Professor of Genetics, Department of Cardio-Thoracic Surgery, Golden Jubilee National Hospital, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Alessandra","sequence":"additional","affiliation":[{"name":"Professor of Genetics, Doctorate School of Oncology and Genetic, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Spina","sequence":"additional","affiliation":[{"name":"Consultant Pathologist, Department of Pathology, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Luca","sequence":"additional","affiliation":[{"name":"Professor of Thoracic Surgery, Department of Thoracic Surgery, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Piero","sequence":"additional","affiliation":[{"name":"Professor of Thoracic Surgery, Department of Thoracic Surgery, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mohiyaddin","sequence":"additional","affiliation":[{"name":"Professor of Genetics, Department of Cardio-Thoracic Surgery, Golden Jubilee National Hospital, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Asif","sequence":"additional","affiliation":[{"name":"Professor of Genetics, Department of Cardio-Thoracic Surgery, Golden Jubilee National Hospital, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A JB","family":"Kirk","sequence":"additional","affiliation":[{"name":"Professor of Genetics, Department of Cardio-Thoracic Surgery, Golden Jubilee National Hospital, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gotti","family":"Giuseppe","sequence":"additional","affiliation":[{"name":"Professor of Thoracic Surgery, Department of Thoracic Surgery, University Hospital of Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"bibr1-0036933013518147","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(78)80131-2"},{"key":"bibr2-0036933013518147","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11099"},{"key":"bibr3-0036933013518147","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.10.001"},{"key":"bibr4-0036933013518147","doi-asserted-by":"publisher","DOI":"10.3109\/02841868109130192"},{"key":"bibr5-0036933013518147","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0003-4975(10)63114-1","volume":"28","author":"Bergh NP","year":"1979","journal-title":"Clinicopathological studies on thymomas. 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