{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:28:01Z","timestamp":1791937681785,"version":"4.3.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Methadone is a synthetic opioid which is being used with increased frequency in the palliative care setting for management of complex pain. There have been cases published reporting the development of oedema with methadone maintenance therapy but no cases on the association with methadone and peripheral oedema in the palliative care setting. As yet, the underlying mechanisms are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This case report describes a gentleman with ependymoma and difficult-to-control lower back pain and scrotal pain. This pain had failed to respond to other strong opioids. He was prescribed methadone and then subsequently developed bilateral peripheral oedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case management<\/jats:title>\n                    <jats:p>Peripheral oedema resolved following cessation of methadone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This highlights an important potential adverse effect of methadone in a society of increased methadone prescription for pain control. The published literature to date is reviewed and possible underlying mechanisms explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0036933014530057","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T01:32:38Z","timestamp":1395970358000},"page":"e11-e13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Methadone and oedema in the palliative care setting: a case report and review of the literature"],"prefix":"10.1177","volume":"59","author":[{"given":"Camilla","family":"Dawson","sequence":"first","affiliation":[{"name":"Palliative Medicine Registrar, Department of Palliative Care, Ninewells Hospital, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Paterson","sequence":"additional","affiliation":[{"name":"Specialty Doctor, Department of Palliative Care, Ninewells Hospital, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"McFatter","sequence":"additional","affiliation":[{"name":"Palliative Medicine Consultant, Department of Palliative Care, Ninewells Hospital, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deans","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Clinical Lead and Palliative Medicine Consultant, Department of Palliative Care, Ninewells Hospital, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"bibr1-0036933014530057","doi-asserted-by":"crossref","unstructured":"Nicholson AB. Methadone for cancer pain.\n                      Cochrane Database Syst Rev\n                      2007; 17: CD003971.","DOI":"10.1002\/14651858.CD003971.pub3"},{"key":"bibr2-0036933014530057","doi-asserted-by":"publisher","DOI":"10.3109\/10826087909054585"},{"key":"bibr3-0036933014530057","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060553"},{"key":"bibr4-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00404-9"},{"key":"bibr5-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(91)90006-V"},{"key":"bibr6-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0712-1"},{"key":"bibr7-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283311e13"},{"key":"bibr8-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1177\/082585979100700202"},{"key":"bibr9-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90125-9"},{"key":"bibr10-0036933014530057","doi-asserted-by":"publisher","DOI":"10.1177\/0269216310373526"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933014530057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0036933014530057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933014530057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:16:13Z","timestamp":1777630573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0036933014530057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/0036933014530057"],"URL":"https:\/\/doi.org\/10.1177\/0036933014530057","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}