{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:05:17Z","timestamp":1777899917395,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T00:00:00Z","timestamp":1485043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is a rare chronic inflammatory disorder of the central nervous system. Herein, we describe the case of a 62-year-old female who presented with right sided facial tingling, gait ataxia and diplopia. Neuroimaging revealed pontine curvilinear enhancing lesions with extension into cerebellar peduncles, characteristic of CLIPPERS. This report discusses the differential diagnosis and the importance of prolonged immunomodulatory treatment for this rare neuro-inflammatory disorder. Long-term immunosuppression appears to be mandatory in order to achieve sustained remission and prevent disability related to atrophy of the structures involved in repeated attacks.<\/jats:p>","DOI":"10.1177\/0036933016689006","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:32:13Z","timestamp":1485131533000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["CLIPPERS and the need for long-term immunosuppression"],"prefix":"10.1177","volume":"62","author":[{"given":"Tarig M","family":"Abkur","sequence":"first","affiliation":[{"name":"Neurology registrar, Department of Neurology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Kearney","sequence":"additional","affiliation":[{"name":"Neurology registrar, Department of Neurology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Consultant Neurologist, Department of Neurology, University Hospital Galway, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,22]]},"reference":[{"key":"bibr1-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq164"},{"key":"bibr2-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh721"},{"key":"bibr3-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21226"},{"key":"bibr4-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0775-0"},{"key":"bibr5-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70511-6"},{"key":"bibr6-0036933016689006","first-page":"880","volume":"25","author":"Prayer D","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr7-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301054"},{"key":"bibr8-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.122"},{"key":"bibr9-0036933016689006","doi-asserted-by":"crossref","unstructured":"Lane C, Phadke R and Howard R. An extended chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids phenotype.\n                      BMJ Case Rep\n                      25 June 2014. doi: 10.1136\/bcr-2014-204117.","DOI":"10.1136\/bcr-2014-204117"},{"key":"bibr10-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12204"},{"key":"bibr11-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0724-0"},{"key":"bibr12-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr134"},{"key":"bibr13-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.10.017"},{"key":"bibr14-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.2016"},{"key":"bibr15-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182648b77"},{"key":"bibr16-0036933016689006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.01.032"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933016689006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0036933016689006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933016689006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:18:00Z","timestamp":1777630680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0036933016689006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,22]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/0036933016689006"],"URL":"https:\/\/doi.org\/10.1177\/0036933016689006","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,22]]}}}