{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:44:36Z","timestamp":1780425876854,"version":"3.54.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>The European guidelines for diagnosing coeliac disease in children were revised in 2012. These recommend that in symptomatic children, a diagnosis of coeliac disease can be made without small-bowel biopsies provided their anti-tissue transglutaminase (anti-tTG) titre is &gt;10 times of upper-limit-of-normal (&gt;10\u00d7ULN) and anti-endomysial antibody is positive. In order to firm up the diagnosis in these children with very high anti-tTG titre, HLA-DQ2\/DQ8 should be checked and be positive. Approximately 25\u201340% of white Caucasian population has HLA-DQ2\/DQ8 haplotype. However, only 0.1\u20131% of the population will develop coeliac disease. Therefore, HLA-DQ2\/DQ8 testing must not be done to \u2018screen\u2019 or \u2018diagnose\u2019 children with coeliac disease. Its use by paediatricians should be limited to children with anti-tTG&gt;10\u00d7ULN, where the diagnosis of coeliac disease is being made on serology alone. A review of case referrals made to a tertiary paediatric gastroenterology centre in Southwest England demonstrated that HLA-DQ2\/DQ8 testing is being requested inappropriately both in primary and secondary care suggesting a poor understanding of its role in diagnosis of coeliac disease. This article aims to clarify the role of HLA-DQ2\/DQ8 testing for clinicians working in non-specialist settings.<\/jats:p>","DOI":"10.1177\/0036933016689008","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T01:27:25Z","timestamp":1484357245000},"page":"25-27","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Limited role of HLA DQ2\/8 genotyping in diagnosing coeliac disease"],"prefix":"10.1177","volume":"62","author":[{"given":"Siba P","family":"Paul","sequence":"first","affiliation":[{"name":"Consultant Paediatrician, Department of Paediatrics, Torbay Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hoghton","sequence":"additional","affiliation":[{"name":"Senior General Practitioner, Clevedon Medical Centre, Clevedon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Consultant in Paediatric Gastroenterology, Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, UK"},{"name":"Honorary Professor in Paediatric Gastroenterology, Joint Centre for Child and Adolescent Health, University of Bristol and University of the West of England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"bibr1-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"bibr2-0036933016689008","unstructured":"National Institute for Health and Care Excellence (September 2015). Coeliac disease: recognition, assessment and management. NICE guidelines 20. NICE: London, www.nice.org.uk\/guidance\/ng20 (accessed 29 December 2016)."},{"key":"bibr3-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7435.322"},{"key":"bibr4-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31812e5710"},{"key":"bibr5-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303996"},{"key":"bibr6-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309754"},{"key":"bibr7-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1038\/ng2058"},{"key":"bibr8-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06044.x"},{"key":"bibr9-0036933016689008","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.113"},{"key":"bibr10-0036933016689008","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MPG.0000000000000938","volume":"62","author":"Paul S","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933016689008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0036933016689008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0036933016689008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:18:01Z","timestamp":1777630681000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0036933016689008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/0036933016689008"],"URL":"https:\/\/doi.org\/10.1177\/0036933016689008","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}