{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:44:49Z","timestamp":1790815489138,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>In 1842, when John Goodsir was Conservator to the Museum of the RCSEd, he saw a 19-year-old male patient who vomited a large volume of acidic, fermented-smelling, watery fluid every morning. Under his microscope, Goodsir found the vomitus to be populated with a micro-organism he named Sarcina ventriculi, which he considered to be causative. In so-doing, Goodsir became one of the first people to link a specific micro-organism with a disease. Goodsir recommended small doses of creosote as an antiseptic and claimed that the boy was eventually cured of the vomiting condition. In August of 1863 Charles Darwin was hugely celebrated by the scientific community and the public, but he had suffered from severe stomach problems all his adult life and at this point, he was vomiting daily. He read Goodsir\u2019s paper and contacted him and asked if he could send some vomitus samples to Edinburgh in the hope that Goodsir might find Sarcina in it and solve the mystery of his debilitating stomach symptoms and perhaps cure them with creosote. Goodsir examined samples in his microscope, but failed to find Sarcina. Sadly, Darwin went on to suffer constantly from severe stomach problems, recently attributed to lactose intolerance, until he died in 1882, some 20\u2009years later.<\/jats:p>","DOI":"10.1177\/0036933020912329","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T23:11:06Z","timestamp":1585091466000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["John Goodsir: discovering\n                    <i>Sarcina ventriculi<\/i>\n                    and diagnosing Darwin\u2019s dyspepsia"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-5766","authenticated-orcid":false,"given":"Ken","family":"Donaldson","sequence":"first","affiliation":[{"name":"Senior Research Fellow, Surgeons' Hall Museums, Edinburgh and Emeritus Professor of Respiratory Toxicology, University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Henry","sequence":"additional","affiliation":[{"name":"Director of Heritage, Surgeons' Hall Museums, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"bibr1-0036933020912329","first-page":"469","volume-title":"The anatomical memoirs of John Goodsir","volume":"1","author":"Lonsdale H","year":"1868"},{"key":"bibr2-0036933020912329","doi-asserted-by":"publisher","DOI":"10.1177\/0967772015591716"},{"key":"bibr3-0036933020912329","doi-asserted-by":"crossref","unstructured":"Virchow RLK.\n                      Cellular pathology\n                      . (As based upon physiological and pathological histology. 1863 English translation of the second German edition by F. Chance.) London: Dover Publications Inc. 1971, p.554.","DOI":"10.5962\/bhl.title.32770"},{"key":"bibr4-0036933020912329","first-page":"1675","author":"Jacyna LS.","year":"1983","journal-title":"J History Biol"},{"key":"bibr5-0036933020912329","first-page":"430","volume":"57","author":"Goodsir J.","year":"1842","journal-title":"Edinburgh Med Surg J"},{"key":"bibr6-0036933020912329","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(199812)14:16<1439::AID-YEA339>3.0.CO;2-Z"},{"key":"bibr7-0036933020912329","unstructured":"Sumner G and, D\u2019Amato R.\n                      Arms and armour of the Imperial Roman Soldier: from Marius to Commodus\n                      . Barnsley: Frontline Books 2009, 320 pp."},{"key":"bibr8-0036933020912329","doi-asserted-by":"crossref","unstructured":"Goodsir J. Anatomy and Development of the Cystic Entozoa. 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