{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:06:41Z","timestamp":1777900001065,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Urinary bladder recurrences (UBRs) after radical nephroureterectomy (RNUx) are a known challenge in patients with upper-tract urothelial cancers (UTUCs). We aim to assess factors associated with UBR and clonal-relatedness with resected UTUC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent RNUx for UTUC between 1998 and 2015 in five institutions were identified. Clonal relatedness between primary UTUC and subsequent UBR in a sub-cohort was assessed using next-generation sequencing. A Kaplan\u2013Meier curve was used to assess differences in UBR between two groups (with or without ureteroscopic biopsy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 267 patients with complete records, 73 (27.3%) had UBR during follow-up. The five-year UBR-free survival in all patients was 64.7%. The five-year UBR-free-survival was inferior in patients who underwent URS biopsy compared with patients who did not undergo ureteroscopic biopsy (49.9% vs 76.4%, p\u2009&lt;\u20090.001). History of bladder tumour (HR, 95% CI; 2.94, 1.73\u20135.00, p\u2009&lt;\u20090.001), ureteroscopic biopsy (HR, 95% CI; 2.21, 1.38\u20133.53, p\u2009=\u20090.001) and preoperative urine cytology \u2265C3 (HR, 95% CI; 2.06, 1.24\u20133.40, p\u2009=\u20090.005) were independently associated with UBR. Patients with ureteroscopic biopsy (n\u2009=\u20093\/5) showed identical mutational changes for common genes ( TP53 and FGFR3) between primary UTUC and subsequent UBR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ureteroscopic biopsy of UTUC is a significant risk factor for UBR. Qualitative clonality assessment showed identical mutational signatures between primary UTUC and UBR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00369330221134233","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T11:22:57Z","timestamp":1672226577000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Urinary bladder recurrences following ureteroscopic biopsies of upper tract urothelial cancers: a multi-centre observational study with genomic assessment for clonality"],"prefix":"10.1177","volume":"68","author":[{"given":"Thineskrishna","family":"Anbarasan","sequence":"first","affiliation":[{"name":"College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh","family":"Nissar","sequence":"additional","affiliation":[{"name":"Department of Urology, Pilgrim Hospital, United Lincolnshire NHS Trust, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Turbitt","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Aberdeen Royal Infirmary, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Walls","sequence":"additional","affiliation":[{"name":"Tayside Centre for Genomic Analysis, University of Dundee, Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"McLuckie","sequence":"additional","affiliation":[{"name":"Academic Urology Unit, Division of Imaging Sciences and Technology, University of Dundee, Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Aberdeen Royal Infirmary, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Bourdon","sequence":"additional","affiliation":[{"name":"Division of Cellular Medicine, University of Dundee, Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Tracey","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Aberdeen Royal Infirmary, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Bray","sequence":"additional","affiliation":[{"name":"Division of Cellular Medicine, University of Dundee, Ninewells Hospital, Dundee, UK"},{"name":"Tayside Biorepository (TBR), Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atlaf","family":"Shamsuddin","sequence":"additional","affiliation":[{"name":"Department of Urology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Department of Urology, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjay","family":"Jain","sequence":"additional","affiliation":[{"name":"Pyrah Department of Urology, Leeds Teaching hospitals, NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hislop","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Shekhar","family":"Biyani","sequence":"additional","affiliation":[{"name":"Department of Urology, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam","family":"Nabi","sequence":"additional","affiliation":[{"name":"Academic Urology Unit, Division of Imaging Sciences and Technology, University of Dundee, Ninewells Hospital, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"bibr1-00369330221134233","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"bibr2-00369330221134233","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"bibr3-00369330221134233","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"bibr4-00369330221134233","first-page":"989","volume":"32","author":"Yuan H","year":"2014","journal-title":"Urol Oncol Semin Orig Investig"},{"key":"bibr5-00369330221134233","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.035"},{"key":"bibr6-00369330221134233","first-page":"5","volume":"18","author":"Hwang EC","year":"2019","journal-title":"Cochrane Database Syst 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