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The DNA-antigen binding capacity of lupus sera appear to provide more information than the DNA binding assay alone, in assessing response to therapy and prognosis in this disease. The standard immunofluorescence antinuclear factor test should be used as a screening procedure where possible, and the DNA binding assay done on sera that are positive in titres of 1 in 256 or greater.<\/jats:p>","DOI":"10.1177\/003693307401900403","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T19:31:24Z","timestamp":1484163084000},"page":"171-175","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Significance of Native DNA Antibodies in Systemic Lupus Erythematosus and other Connective Tissue Diseases"],"prefix":"10.1177","volume":"19","author":[{"given":"J.","family":"Webb","sequence":"first","affiliation":[{"name":"University Department of Pathology, Western Infirmary; and The Centre for Rheumatic Diseases University Department of Medicine, Royal Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Whaley","sequence":"additional","affiliation":[{"name":"University Department of Pathology, Western Infirmary; and The Centre for Rheumatic Diseases University Department of Medicine, Royal Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lee","sequence":"additional","affiliation":[{"name":"University Department of Pathology, Western Infirmary; and The Centre for Rheumatic Diseases University Department of Medicine, Royal Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1974,7,1]]},"reference":[{"key":"bibr1-003693307401900403","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105677"},{"key":"bibr2-003693307401900403","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110306"},{"key":"bibr3-003693307401900403","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)91944-4"},{"key":"bibr4-003693307401900403","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90021-6"},{"key":"bibr5-003693307401900403","first-page":"527","volume":"4","author":"Carr R. 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