{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:28:08Z","timestamp":1777901288894,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:p>Three silicon-containing compounds (magnesium trisilicate BP, crushed quartz and crushed Arran granite) were added to the drinking water (250 mg\/l) of three groups of male guinea pigs for four months. At autopsy all animals receiving magnesium trisilicate showed a focal tubulo-interstitial nephritis mainly affecting the distal nephron. Similar but less intense lesions were encountered in two animals receiving crushed quartz. No renal lesions were found in the control group or in animals receiving crushed Arran granite.<\/jats:p>\n                  <jats:p>The concentration of soluble silicates in drinking water, measured as elemental silicon (Si) by atomic absorption spectroscopy (AAS) was determined for twenty-eight locations in different regions of Britain.<\/jats:p>\n                  <jats:p>Following ingestion of magnesium trisilicate, significant increases in urinary excretion of Si were demonstrated in two healthy adults using atomic absorption spectroscopy.<\/jats:p>","DOI":"10.1177\/003693308202700104","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T13:02:47Z","timestamp":1484053367000},"page":"10-16","source":"Crossref","is-referenced-by-count":25,"title":["Silicate Nephrotoxicity in the Experimental Animal: The Missing Factor in Analgesic Nephropathy"],"prefix":"10.1177","volume":"27","author":[{"given":"J. W.","family":"Dobbie","sequence":"first","affiliation":[{"name":"Tenovus Kidney Diseases Research Unit, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J. B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Tenovus Kidney Diseases Research Unit, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"key":"bibr1-003693308202700104","first-page":"205","volume":"61","author":"Kolev K","year":"1970","journal-title":"Med Lavoro"},{"key":"bibr2-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90326-5"},{"key":"bibr3-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1159\/000181988"},{"key":"bibr4-003693308202700104","unstructured":"World Health Organisation, Regional Office for Europe. Planning conference on the endemic nephropathy of South Eastern Europe, Dubrovnik, 1964."},{"key":"bibr5-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711030105"},{"key":"bibr6-003693308202700104","first-page":"75","volume":"3","author":"Gye WE","year":"1922","journal-title":"Br J Exp Path"},{"key":"bibr7-003693308202700104","first-page":"157","volume":"23","author":"Forman SA","year":"1959","journal-title":"Canad J Comp Med"},{"key":"bibr8-003693308202700104","first-page":"599","volume":"15","author":"Schepers GWH","year":"1957","journal-title":"AMA Arch Industr Hlth"},{"key":"bibr9-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.65.4.872"},{"key":"bibr10-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.3917.205"},{"key":"bibr11-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1007\/BF02999386"},{"key":"bibr12-003693308202700104","unstructured":"The silicates in food. Brit Food J 1971; 80."},{"key":"bibr13-003693308202700104","unstructured":"Report on further classes of food additives. Ministry of Agriculture, Fisheries and Food. HMSO, London 1968; 27."},{"key":"bibr14-003693308202700104","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600680220"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693308202700104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693308202700104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:57:30Z","timestamp":1777633050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/003693308202700104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1177\/003693308202700104"],"URL":"https:\/\/doi.org\/10.1177\/003693308202700104","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}