{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:28:15Z","timestamp":1777901295834,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1982,1,1]],"date-time":"1982-01-01T00:00:00Z","timestamp":378691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scott Med J"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:p>Despite Scotland's well-recognised alcohol problem, there is scant information on the aetiology of cirrhosis in this country. This study of 222 patients, reviewed 197 cases presenting as cirrhosis and 25 cases presenting as primary liver cell carcinoma (PLCC) in the East Tayside area of Scotland between 1975 and 1979.<\/jats:p>\n                  <jats:p>The survey was based on an analysis of all histologically proven cases of cirrhosis and PLCC encountered during a five-year period. There was a constant rate of presentation of cirrhosis of about 40 new patients per year, with a stable pattern of aetiology. About 55 per cent were due to alcohol, and there was no significant change in this proportion over the study. No evidence was found for an increasing female susceptibility or earlier female morbidity in alcoholic cirrhosis. Cryptogenic cirrhosis, cardiac cirrhosis and secondary biliary cirrhosis were more often diagnosed at post mortem. Ninety one per cent of patients with primary biliary cirrhosis were females, but the expected male preponderance in haemochromatosis was not present.<\/jats:p>\n                  <jats:p>In addition to the 25 patients presenting with PLCC, three of the cirrhotic patients developed the tumour by the end of 1979. Seventy one per cent of PLCC cases arose in already cirrhotic livers, none were HBsAg positive.<\/jats:p>\n                  <jats:p>Bronchopneumonia, hepatic failure, gastrointestinal bleeding and cardiac failure were the most frequent causes of death.<\/jats:p>","DOI":"10.1177\/003693308202700107","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T13:02:47Z","timestamp":1484053367000},"page":"29-36","source":"Crossref","is-referenced-by-count":2,"title":["Cirrhosis and Primary Liver Cell Carcinoma in Tayside"],"prefix":"10.1177","volume":"27","author":[{"given":"W. S.","family":"Hislop","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, Ninewells Hospital and Medical School, Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Masterton","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Ninewells Hospital and Medical School, Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A. D.","family":"Bouchier","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Ninewells Hospital and Medical School, Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hopwood","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, Ninewells Hospital and Medical School, Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,1,1]]},"reference":[{"key":"bibr1-003693308202700107","first-page":"86","volume":"13","author":"Sclare AB","year":"1978","journal-title":"British Journal on Alcohol and Alcoholism"},{"key":"bibr2-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582085"},{"key":"bibr3-003693308202700107","volume-title":"Report of the Departmental Committee on Scottish Licensing Law","author":"Clayson C.","year":"1973"},{"key":"bibr4-003693308202700107","first-page":"12","volume":"22","author":"Morrison SL","year":"1964","journal-title":"Health Bull"},{"key":"bibr5-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6266.819-b"},{"key":"bibr6-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92845-2"},{"key":"bibr7-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)91064-7"},{"key":"bibr8-003693308202700107","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1966.tb19475.x"},{"key":"bibr9-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.2.108"},{"key":"bibr10-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.27.8.669"},{"key":"bibr11-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.26.12.936"},{"issue":"4","key":"bibr12-003693308202700107","first-page":"521","volume":"55","author":"Anthony PP","year":"1977","journal-title":"Bull WHO"},{"key":"bibr13-003693308202700107","first-page":"191","volume":"20","author":"Pequignot G","year":"1974","journal-title":"Revue de l'alcoolism"},{"key":"bibr14-003693308202700107","first-page":"193","volume-title":"Recent advances in histopathology","author":"MacSween RNM","year":"1978"},{"key":"bibr15-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309272891306"},{"key":"bibr16-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/25.8.902"},{"key":"bibr17-003693308202700107","first-page":"788","volume-title":"Liver and biliary disease","author":"Powell LW","year":"1979"},{"key":"bibr18-003693308202700107","unstructured":"Edmondson HA, Peters RL. In Anderson WAD, Kissane JM, eds. Pathology. St Louis: Mosbby, 1977:1403\u20131404."},{"key":"bibr19-003693308202700107","first-page":"848","volume-title":"Liver and biliary disease","author":"Hodstock G","year":"1979"},{"key":"bibr20-003693308202700107","first-page":"338","volume-title":"Liver and Biliary Disease","author":"Bissel DM","year":"1979"},{"key":"bibr21-003693308202700107","unstructured":"Sherlock S. Diseases of the liver and biliary system. Oxford: Blackwell, 1975:529."},{"key":"bibr22-003693308202700107","unstructured":"Trulove SC, Reynell PC. Diseases of the digestive system. Oxford: Blackwell 1963:583."},{"key":"bibr23-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1963.tb17431.x"},{"key":"bibr24-003693308202700107","first-page":"119","volume":"37","author":"Stone WD","year":"1968","journal-title":"Q J Med"},{"key":"bibr25-003693308202700107","unstructured":"Sherlock S. Diseases of the liver and biliary system. Oxford: Blackwell, 1975:433."},{"key":"bibr26-003693308202700107","first-page":"336","volume-title":"Alcoholic cirrhosis and other toxic hepatopathias","author":"Hallen J","year":"1970"},{"key":"bibr27-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5840.608-c"},{"key":"bibr28-003693308202700107","first-page":"13","volume":"9","author":"Jain S","year":"1973","journal-title":"Midland Medical Review"},{"key":"bibr29-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.11.1022"},{"key":"bibr30-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91193-5"},{"key":"bibr31-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6260.263"},{"key":"bibr32-003693308202700107","first-page":"23","volume-title":"Symposium Franco-Britannique sur l'alcoolisme","author":"Pequignot G","year":"1975"},{"key":"bibr33-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6066.939"},{"key":"bibr34-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6247.1069-d"},{"key":"bibr35-003693308202700107","first-page":"52","volume":"8","author":"Barry M","year":"1973","journal-title":"J R Coll Physicians Lond"},{"key":"bibr36-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.46.534.200"},{"key":"bibr37-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1177\/003591575705000303"},{"key":"bibr38-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90143-2"},{"key":"bibr39-003693308202700107","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/68.1.1"}],"container-title":["Scottish Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693308202700107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003693308202700107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:57:32Z","timestamp":1777633052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/003693308202700107"}},"subtitle":["A Five Year Study"],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1177\/003693308202700107"],"URL":"https:\/\/doi.org\/10.1177\/003693308202700107","relation":{},"ISSN":["0036-9330","2045-6441"],"issn-type":[{"value":"0036-9330","type":"print"},{"value":"2045-6441","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}