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Thirty-nine of the 139 patients had had jaundice or hepatitis and 56 had a positive test for HBsAb in the blood although few of these had had an identifiable clinical illness. Fifty-eight haemophiliacs had elevated serum aminotransferases at the time of study, but the five year review revealed only six patients who had had persistently abnormal results, although none had clinically evident liver disease. Liver dysfunction was unrelated to a history of hepatitis, to a positive HBsAb test, or to age, type of haemophilia, factor level or frequency of factor replacement treatment. Abnormalities of liver function in haemophilia appear to be unrelated to past or present hepatitis B infection in most cases and may not be related to any single transmitted infectious agent.<\/jats:p>","DOI":"10.1177\/003693308603100209","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T04:57:50Z","timestamp":1484283470000},"page":"103-108","source":"Crossref","is-referenced-by-count":0,"title":["Liver Dysfunction in Haemophilia"],"prefix":"10.1177","volume":"31","author":[{"given":"M.M.","family":"Steven","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Small","sequence":"additional","affiliation":[{"name":"Centre for Rheumatic Diseases and the University Department of Medicine, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pettigrew","sequence":"additional","affiliation":[{"name":"Royal Hospital for Sick Children, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.D.O.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Centre for Rheumatic Diseases and the University Department of Medicine, Glasgow Royal Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.D.","family":"Sturrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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