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The computation of control strategies by MPC uses a simplified model of the network dynamics. The use of the combined approach of optimization and simulation contributes to making sure that the effect of more complex dynamics, better represented by the simulation model, may be taken into account. Coordination between simulator and optimizer works in a feedback scheme, from which both real-time interaction and extensive validation of the proposed solution have been realized using a case study based on the Catalunya regional water network.<\/jats:p>","DOI":"10.1177\/0037549714559982","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:33:45Z","timestamp":1418776425000},"page":"59-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated simulation and optimization scheme of real-time large-scale water supply network: applied to Catalunya case study"],"prefix":"10.1177","volume":"91","author":[{"given":"Cong Cong","family":"Sun","sequence":"first","affiliation":[{"name":"Advanced Control Systems Group at the Institut de Rob\u00f2tica i Inform\u00e0tica Industrial (CSIC-UPC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicen\u00e7","family":"Puig","sequence":"additional","affiliation":[{"name":"Advanced Control Systems Group at the Institut de Rob\u00f2tica i Inform\u00e0tica Industrial (CSIC-UPC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Cembrano","sequence":"additional","affiliation":[{"name":"Advanced Control Systems Group at the Institut de Rob\u00f2tica i Inform\u00e0tica Industrial (CSIC-UPC), Barcelona, Spain"},{"name":"CETaqua, Water Technology Centre, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"bibr1-0037549714559982","doi-asserted-by":"publisher","DOI":"10.1080\/02508060008686799"},{"key":"bibr2-0037549714559982","doi-asserted-by":"publisher","DOI":"10.1007\/s11269-009-9488-0"},{"key":"bibr3-0037549714559982","unstructured":"Molina M. 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