{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:46:32Z","timestamp":1777902392178,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SIMULATION"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Oncology clinics are often burdened with scheduling large volumes of cancer patients for chemotherapy under limited resources, such as nurses and chemotherapy chairs. Chemotherapy is a cancer treatment method that is administered orally or intravenously at an outpatient oncology clinic. Chemotherapy patients require a treatment regimen, which is a series of appointments over several weeks or months prescribed by the oncologist. The timing of these appointments is critical to the effectiveness of the chemotherapy treatment on cancer. This motivates the need for new methods for making efficient appointment schedules and for assessing clinic operation performance from both patient and management perspectives. This work uses a classic modeling approach based on systems theory to develop a discrete event system specification (DEVS) simulation model for oncology clinic operations called DEVS-CHEMO. DEVS-CHEMO is configurable to any oncology clinic and provides several capabilities for oncology clinic managers. For example, it can simulate scheduling of chemotherapy patients, clinic resources, and the arrival process of the patients to the clinic on the day of their appointment. This model simulates oncology clinic operations as patients receive chemotherapy treatments and thus allows for assessing scheduling algorithms using both patient and management perspectives. DEVS-CHEMO has been tested and validated using historical data from a real outpatient oncology clinic and the simulation results reported in this paper provide several insights regarding oncology clinic operations management.<\/jats:p>","DOI":"10.1177\/0037549717708246","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T10:00:37Z","timestamp":1496224837000},"page":"105-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Modeling and simulation of oncology clinic operations in discrete event system specification"],"prefix":"10.1177","volume":"94","author":[{"given":"Michelle M","family":"Alvarado","sequence":"first","affiliation":[{"name":"Department of Industrial and Systems Engineering, Texas A&M University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanisha G","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Industrial and Systems Engineering, Texas A&M University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Ntaimo","sequence":"additional","affiliation":[{"name":"Department of Industrial and Systems Engineering, Texas A&M University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Ingram School of Engineering, Texas State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Health System, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"bibr1-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq495"},{"key":"bibr2-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1080\/19488300.2012.665155"},{"key":"bibr3-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2011.000281"},{"key":"bibr4-0037549717708246","volume-title":"Theory of modeling and simulation","author":"Zeigler BP","year":"2000"},{"key":"bibr5-0037549717708246","volume-title":"Theory of modeling and simulation","author":"Zeigler BP.","year":"1976"},{"key":"bibr6-0037549717708246","author":"Zeigler BP","year":"2003","journal-title":"Arizona State University"},{"key":"bibr7-0037549717708246","first-page":"109","volume":"11","author":"Langhorn M","year":"2001","journal-title":"Can Oncol Nurs J"},{"issue":"6","key":"bibr8-0037549717708246","first-page":"34","volume":"24","author":"Hawley E","year":"2009","journal-title":"J Assoc Commun Canc Cent Oncol Iss"},{"key":"bibr9-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1191\/1078155203jp105oa"},{"key":"bibr10-0037549717708246","first-page":"18","volume":"3","author":"Rosenburg K.","year":"2010","journal-title":"J Multidisc Canc Care"},{"key":"bibr11-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1188\/05.ONF.535-538"},{"key":"bibr12-0037549717708246","volume-title":"Patient safety and quality: an evidence-based handbook for nurse","author":"Jennings BM.","year":"2008"},{"key":"bibr13-0037549717708246","first-page":"1","volume":"9","author":"Kidd M","year":"2014","journal-title":"Am Nurse Today"},{"key":"bibr14-0037549717708246","author":"Chan JYT","year":"2011","journal-title":"Department of Mechanical and Industrial Engineering, University of Toronto"},{"key":"bibr15-0037549717708246","first-page":"513","volume-title":"proceedings of the 2011 automation science and engineering (CASE) conference","author":"Sadki A"},{"key":"bibr16-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(12)38071-9"},{"key":"bibr17-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1007\/s10729-014-9268-0"},{"key":"bibr18-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2013.10.012"},{"key":"bibr19-0037549717708246","doi-asserted-by":"publisher","DOI":"10.1287\/inte.2013.0695"},{"key":"bibr20-0037549717708246","unstructured":"P\u00e9rez-Roman E. 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