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Most often, the diverse perspectives of healthcare systems are studied in isolation and using specific formalisms. As it turns out, answering questions concerning behavioral properties of the overall system becomes difficult and therefore not sufficient for an efficient design and analysis of the system under study. In this article, we propose a framework for multi-paradigm modeling and holistic simulation of healthcare systems. We present a modeling methodology with a plethora of formalisms to allow the modeler to choose an appropriate formalism at a given level of abstraction while model transformation relates the different formalisms. Furthermore, we develop an integrative approach for the interactions between models of different perspectives through dynamic update of model output-to-parameter integration during concurrent simulations. Such an approach provides multiple levels of explanation for the same system, while offering, at the same time, an integrated view of the whole. The framework has successfully been applied to study part of the Nigerian healthcare system.<\/jats:p>","DOI":"10.1177\/0037549717744888","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T09:33:02Z","timestamp":1512725582000},"page":"235-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["A model-driven framework for multi-paradigm modeling and holistic simulation of healthcare systems"],"prefix":"10.1177","volume":"94","author":[{"given":"Ignace","family":"Djitog","sequence":"first","affiliation":[{"name":"Computer Science Department, African University of Science & Technology, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamzat O","family":"Aliyu","sequence":"additional","affiliation":[{"name":"School of ICT, Federal University of Technology, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou K","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"LIMOS CNRS UMR 6158, Universit\u00e9 Clermont Auvergne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"bibr1-0037549717744888","unstructured":"World Health Organization. 2014. 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